| abstract |
This refers to a piperidine compound represented by formula (1) wherein: ring A is an optionally substituted benzene ring, ring B is an optionally substituted benzene ring, R1 is H atom or a substituent for the amino group , R2 is an H atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is an O or -N atom (R3) -, R3 is an atom of H or an optionally substituted alkyl group; R4a and R4b can be the same or different, and each is an H atom or an optionally substituted alkyl group, or they can be linked together at both ends to form an alkylene group, or a pharmaceutically acceptable salt thereof that has an excellent antagonistic action. to the tachykinin receptor. |