| abstract |
This refers to the compounds of the general formula (1), wherein: R 1 is cycloalkyl, substituted by OR or is 2- (7-oxa-bicyclo [2.2.1] hept-1-yl) -ethyl; R is hydrogen, lower alkyl or C (O)-lower alkyl; X is -CHR'-; and R 'is hydrogen or lower alkyl; and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof for Alzheimer's disease, Parkinson's disease, Huntington's disease, neuroprotection, schizophrenia, anxiety, pain, shortness of breath, depression, ADHD, drug addiction, such as amphetamine, cocaine, opioids, ethanol, nicotine, cannabinoids, or for the treatment of asthma, allergic responses, hypoxia, ischemia, seizures and substance abuse, or for the use of sedatives, muscle relaxants, antipsychotics, antiepileptics , anticonvulsants and cardioprotective agents for coronary artery disease and heart failure. |