abstract |
Substituted aminocarbonyl phenyl compounds. These are useful for therapy, in particular, for pain control. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt thereof, diastereomers, enantiomers or mixtures thereof wherein: m is selected from 0, 1 and 2; n is selected from 0, 1, 2, 3, 4 and 5; R1 is independently selected from halogen, cyano, amino, nitro, C1-6 alkylamino, C1-6 dialkylamino, acetylamino, hydroxy, C1-6 alkoxy, C1-6 alkyl, halogenated C1-6 alkoxy, C1-6 alkenyl and C1 alkyl -6 halogenated; R2 is selected from C6-10 aryl and C2-10 heterocyclyl; wherein said C6-10 aryl and C2-10 heterocyclyl used in the definition of R2 are optionally substituted with one or more groups selected from halogen, halogenated C1-6 alkyl, C1-6 alkyl, cyano, nitro, halogenated C1-6 alkoxy, hydroxy, C1-6 hydroxyalkyl, amino, C1-6 alkoxy-C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylamino, C1-6 dialkylamino, C1-6 aminoalkyl, C3-6 cycloalkyl, heteroaryl C2-6, C1-6 heteroarylalkyl, C6-10 aryl and C6-10 aryl-C1-6 alkyl; and R3 is selected from H and C1-6 alkyl; R4 is selected from C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, C2-6 heterocyclylamino, C2-6 heterocyclyloxy and C2-6 heterocyclyl; wherein said C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, C6-10 aryl, C2-6 heterocyclylamino, C2-6 heterocyclyloxy and C2-6 heterocyclyl used in the definition of R4 are optionally substituted with one or more groups selected from halogen, halogenated C1-6 alkyl, C1-6 alkyl, cyano, nitro, C1-6 alkoxy, halogenated C1-6 alkoxy, hydroxy, C1-6 hydroxyalkyl, amino, C1-6 alkoxy-C1-6 alkyl, alkylcarbonyl C1-6, C1-6 alkoxycarbonyl, C1-6 alkylamino, C1-6 dialkylamino, C1-6 aminoalkyl, C3-6 cycloalkyl, C2-6 heteroaryl, C1-6 heteroarylalkyl, C6-10 aryl, and C6-10- aryl C1-6 alkyl; or the remainder of formula (2) is C2-10 heterocyclyl, which is optionally substituted with one or more groups selected from halogen, C1-6 alkyl substituted halogen, C1-6 alkyl, cyano, nitro, C1-6 alkoxy, alkoxy Halogenated C1-6, hydroxy, hydroxy-C1-6 alkyl, amino, C1-6 alkoxy-C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylamino, C1-6 dialkylamino, C1-6 aminoalkyl , C3-6 cycloalkyl, C2-6 heteroaryl, C1-6 heteroarylalkyl, C6-10 aryl and C6-10 aryl-C1-6 alkyl. |