http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-049558-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| filingDate | 2005-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab48c608017d41e29b9eafa8edad6464 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a159e26bd03170ae1267aa45593a5f64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b545918c016183bc7119a14c3d196f61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_285d9bd8928b1f89293e0512a143e03f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1ba24996bfa78d58e72feb100824980 |
| publicationDate | 2006-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-049558-A1 |
| titleOfInvention | COMPOUNDS DERIVED FROM FUSED PYRIMIDINS AND THEIR COMPOSITIONS, FOR THE TREATMENT OF INFLAMMATORY AND IMMUNOREGULATORY DISORDERS. |
| abstract | The compounds are useful for the treatment of inflammatory and autoimmune diseases and conditions. Compositions and treatment methods used by the object compounds. For example, the methods are useful for the treatment of inflammatory and immune disorders and diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis and inflammatory bowel disease. Claim 1: A compound having the formula (1), or a pharmaceutically acceptable salt or pro-drug, wherein: A1 and A4 are independently C (Rb) or N; Q is a member selected from the group consisting of a bond, C1-8 alkylene, C2-8 heteroalkylene, -C (O) -, OC (O) -, -CH2CO-, CH2SO and CH2SO2-; L is a C1-5 bond or alkylene; X is -CH2-, SO2 or - C (O) -; Ra is selected from the group consisting of halogen, -OR ', = O, = NR', = N-OR ', -NR'R' ', -SR', -halogen, -SiR'R''R '' ', -OC (O) R', -C (O) R ', -CO2R', -CONR'R '', -OC (O) NR'R '', -NR''C (O) R ' , -NR'-C (O) NR''R '' ', -NR''C (O) 2R', NH-C (NH2) = NH, - NR'C (NH2) = NH, -NH- C (NH2) = NR ', -S (O) R', -S (O) 2R ', -S (O) 2NR'R' ', -CN and -NO2; Rb is selected from the group consisting of halogen, -OR ', = O, = NR', = N-OR ', -NR'R' ', -SR', -halogen, -SiR'R''R '' ', -OC (O) R', -C (O) R ', -CO2R', -CONR'R '', -OC (O) NR'R '', - NR''C (O) R ' , -NR'-C (O) NR''R '' ', -NR''C (O) 2R', NH-C (NH2) = NH, -NR'C (NH2) = NH, -NH- C (NH2) = NR ', -R', -S (O) R ', -S (O) 2R', -S (O) 2NR'R '', -CN and -NO2; the subscript n is 0, 1.2 or 3; each R ', R' ', R' '' is independently H, unsubstituted C1-8 alkyl, heteroalkyl, unsubstituted aryl, or substituted aryl; R1 is heteroaryl or aryl; R2 is a member selected from the group consisting of hydrogen, halogen, C1-10 alkyl, C2-10 heteroalkyl, C1-10 heterocycloalkyl, C1-10 alkylaryl and C2-10 heteroalkylaryl or optionally R2 may be combined with L to form a ring 5-, 6-, 7- or 8- members containing 1 to 3 heteroatoms selected from the group consisting of N, O and S; R3 is absent or is a member selected from the group consisting of -H, -CHR6R7, -S (O) mR5, -S (O) mN (R8) R9, -S (O) mN (R8) CH2R6, -N (R8) SO2R5, -N (R8) CH2R10, or a group of formulas (2), or optionally R3 can be combined with R2 to form a 4-, 5-, 6-, 7-, or 8-membered ring containing 1 to 3 heteroatoms selected from the group consisting of N, O, and S; R4 is a member selected from the group consisting of C1-20 alkyl, C2-20 heteroalkyl, heteroaryl, aryl, C1-6 heteroarylalkyl, C2-6 heteroarylheteroalkyl, C1-6 arylalkyl and C2-6 arylheteroalkyl; R5 is selected from the group consisting of C1-8 alkyl, C2-8 heteroalkyl, aryl and heteroaryl; R6 and R7 are independently hydrogen, C1-8 alkyl or C2-8 heteroalkyl; R8 is hydrogen, C1-8 alkyl, C2-8 heteroalkyl, heteroaryl or aryl; R9 is C1-8 alkyl; R10 is aryl; Z is CH or N; X1 is a bond, C1-6 alkylene or C1-6 heteroalkylene; Y1 is C1-6 alkylene; and the subscript m is 0, 1 or 2. |
| priorityDate | 2004-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID458392451 |
Total number of triples: 45.