http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-049427-A1
Outgoing Links
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| filingDate | 2005-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87cf3f03e205dd628912460aa889fdbf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b3889931e8e47b5020f40f9d9e514fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5167cb2804b621f35691a763eb15ed1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69586642ba4ec4da0ddb412ca56ae5af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b72a94a13da83f457cdeabc51c962f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_028c162de52cb60e2f6e73b494a979dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_256be52f437fe9699197064ebc55f80b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a8ad2b919370673fbadc2266fbbfb6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bf7924a81a6b92eba3c1ae1e9bf1e4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_975aa5aef6e7435b6066ea8d30345eb7 |
| publicationDate | 2006-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-049427-A1 |
| titleOfInvention | TIOUREA COMPOUNDS REPLACED WITH AZABENZOFURAN, VIRAL REPLICATION INHIBITORS |
| abstract | This provides pharmaceutically acceptable compounds and salts of formula (1). Certain compounds of formula (1) described herein possess potent antiviral activity. This provides, in particular, compounds of the formula (1) that are potent and / or selective inhibitors of Hepatitis C virus replication. It also provides pharmaceutical compositions containing one or more compounds of formula (1), or a salt. , acylated solvate or prodrug of said compounds, and one or more pharmaceutically acceptable carriers, excipients or diluents. This also includes methods for treating patients suffering from certain infectious diseases, administering to said patients an amount of a compound of formula (1) that is effective in reducing the signs or symptoms of the disease or disorder. These infectious diseases include viral infections, particularly HCV infections. It includes, in particular, methods for treating human patients suffering from an infectious disease, but also includes methods for treating other animals, including cattle and domesticated companion animals, which suffer from an infectious disease. Treatment methods include the administration of a compound of formula (1) as the only active agent or the administration of a compound of formula (1) in combination with one or more therapeutic agents. Claim 1: A compound or a pharmaceutically acceptable salt, characterized in that the compound is: 1- (4-pentylphenyl) -3- (1,2,3-thiadiazol-4-carbonyl) thiourea; 1- (3- (4-phenyl-benzyloxy) phenyl) -3- (2-morpholinoacetyl) thiourea; 1- (3-Cyanobenzoyl) -3- (3-benzyloxyphenyl) thiourea; 1- (1-methylpiperidine-3-carbonyl) -3- (4-pentyloxyphenyl) thiourea; 1- (1-methylpiperidine-3-carbonyl) -3- (4-pentylphenyl) thiourea; 1- (4- (pentyloxy) phenyl) -3- (quinoxaline-7-carbonyl) thiourea; 1- (4-pentylphenyl) -3- (quinoline-3-carbonyl) thiourea; 1- (4- (pentyloxy) phenyl) -3- (quinoxaline-7-carbonyl) thiourea; 1- (4-pentylphenyl) -3- (quinoxaline-7-carbonyl) thiourea; 1- (2-methyl-5- (trifluoromethyl) oxazol-4-carbonyl) -3- (4-pentylphenyl) thiourea; 1- (2-methyl-5- (trifluoromethyl) oxazol-4-carbonyl) -3- (4- (pentyloxy) phenyl) thiourea; 1- (4-pentylphenyl) -3- (1,2,3-thiadiazol-4-carbonyl) thiourea; 1- (4-pentoxyphenyl) -3- (1,2,3-thiadiazol-4-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (H-imidazo [1,2-a] pyridine-6-carbonyl) thiourea; 1- (1- (2-Amino-2-oxoethyl) -2-oxo-1,2-dihydropyridine-5-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (3-cyclopropyl-4- (pentyloxy) phenyl) -3-nicotinoylthiourea; 1- (1-methyl-2-oxo-1,2-dihydropyridine-5-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (4- (hexyloxy) phenyl) -3- (1-methyl-2-oxo-1,2-dihydropyridine-5-carbonyl) thiourea; methyl 2-oxo-2- (5 - ((3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thioureido) carbonyl) pyridin-2-ylamino) acetate; methyl 2- (5 - ((3- (4- (heptyloxy) phenyl) thioureido) carbonyl) pyridin-2-ylamino) -2-oxoacetate; 1- (4-Pentyloxy-3-trifluoromethyl-phenyl) -3- (pyridine-3-carbonyl) -thiourea; 1- (2- (2-amino-2-oxoacetamido) nicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (5-methyl-4,5,6,7-tetrahydrofuro [3,2-c] pyridine-2-carbonyl) -3- (4- (pentyloxy) phenyl) thiourea; 1- (2- (1H-imidazol-1-yl) acetyl) -3- (4- (pentyloxy) phenyl) thiourea; 1- (4- (pentyloxy) phenyl) -3- (3- (pyridin-3-yl) propanoyl) thiourea; 1- (3-Fluoro-4- (4-phenylpiperidin-1-yl) phenyl) -3-nicotinoylthiourea 1- (4- (cyclohexylmethoxy) -3- fluorophenyl) -3-nicotinoylthiourea 1- (4- (4-hexylbicyclo [2.2.2] octan-1-yl) phenyl) -3-nicotinoylthiourea 1-nicotinoyl-3- (4 - ((1s, 4r) -4-propylcyclohexyl) phenyl) thiourea 1- (4 - ((1s, 4r ) -4-hexylcyclohexyl) phenyl) -3-nicotinoylthiourea; 1- (3-phenoxyphenyl) -3- (2- (pyrrolidin-1-yl) nicotinoyl) thiourea; 1- (3- (benzyloxy) phenyl) -3- (2- (pyrrolidin-1-yl) nicotinoyl) thiourea; 1- (6- (pentyloxy) pyridin-3-yl) -3- (2- (pyrrolidin-1-yl) nicotinoyl) thiourea; 1- (3- (2,3-dihydro-1H-inden-2-yloxy) phenyl) -3- (2- (pyrrolidin-1- yl) nicotinoyl) thiourea; 1- (2- (2- (dimethylamino) ethoxy) nicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (5-methylisoxazol-3-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (4-methyl-1,2,3-thiadiazol-5-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (3-tert-butyl-1-methyl-1 H -pyrazol-5-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (2-methylnicotinoyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (1,3-dimethyl-1 H -pyrazol-5-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (6- (pentyloxy) pyridin-3-yl) -3- (2- (pyridin-4-yl) thiazol-4-carbonyl) thiourea; 1- (6- (pentyloxy) pyridin-3-yl) -3- (2-phenyl-5- (trifluoromethyl) oxazol-4-carbonyl) thiourea; 1- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) -3- (2- (pyridin-3-yl) thiazol-4-carbonyl) thiourea; 1- (2-methyl-1,8-naphthyridine-3-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (2,7-dimethylpyrazolo [1,5-a] pyrimidine-6-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (2-methyl-5- (trifluoromethyl) oxazol-4- carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (4-methyl-2-phenyl-2H-1,2,3-triazol-5-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (5-methylisoxazol-4-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (5-methylisoxazol-3- carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (6- (pentyloxy) pyridin-3-yl) -3- (1,2,3-thiadiazol-4-carbonyl) thiourea; 1- (2-methylH-imidazo [1,2-a] pyridine-3-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (isoxazol-5-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (2-methylnicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (benzo [c] [1,2,5] oxadiazol-6-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) -3- (2- (pyridin-4- yl) thiazol-4-carbonyl) thiourea; 1- (1,3-dimethyl-1 H -thieno [2,3-c] pyrazol-5-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (2-methyl-1,8-naphthyridine-3-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (2-methyl-5- (trifluoromethyl) oxazol-4- carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) -3- (1,2,3-thiadiazol-4-carbonyl) thiourea; 1- (isoxazol-5-carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (benzo [c] [1,2,5] oxadiazol-6- carbonyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (4-methyl-1,2,3-thiadiazol-5-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (4-methyl-1,2,3-thiadiazol-5-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (2- (pyridin-3-yl) thiazol-4-carbonyl) thiourea; 1- (2,7-dimethylpyrazolo [1,5-a] pyrimidine-6-carbonyl) -3- (3-fluoro-4- (pentyloxy) phenyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (4-methyl-2-phenyl-2H-1,2,3-triazol-5-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (5-methylisoxazol-4-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (5-methylisoxazol-3-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (2- (pyridin-4-yl) thiazol-4-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (2-phenyl-5- (trifluoromethyl) oxazol-4-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (2-methyl-1,8-naphthyridine-3-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (2-methyl-5- (trifluoromethyl) oxazol-4-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (1,2,3-thiadiazol-4-carbonyl) thiourea; 1- (3-fluoro-4- (pentyloxy) phenyl) -3- (isoxazol-5-carbonyl) thiourea; 1- (benzo [c] [1,2,5] oxadiazol-6-carbonyl) -3- (3-fluoro-4- (pentyloxy) phenyl) thiourea; 1- (1,3-dimethyl-1 H -thieno [2,3-c] pyrazol-5-carbonyl) -3- (3-fluoro-4- (pentyloxy) phenyl) thiourea; 1- (4-methyl-1,2,3-thiadiazol-5-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (1,3-dimethyl-1 H -pyrazol-5-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (6- (pentyloxy) pyridin-3-yl) -3- (2- (pyridin-3-yl) thiazol-4-carbonyl) thiourea; 1- (2,7-dimethylpyrazolo [1,5-a] pyrimidine-6-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (4-methyl-2-phenyl-2H-1,2,3-triazol-5-carbonyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (3- (benzyloxy) phenyl) -3- (2- (4-methylpiperazin-1- yl) nicotinoyl) thiourea; 1- (2- (4-methylpiperazin-1-yl) nicotinoyl) -3- (3-phenoxyphenyl) thiourea; 1- (2- (4-methylpiperazin-1-yl) nicotinoyl) -3- (4-pentylphenyl) thiourea; 1- (2- (4-methylpiperazin-1-yl) nicotinoyl) -3- (4- (pentyloxy) phenyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (2- (4-methylpiperazin-1-yl) nicotinoyl) thiourea; 1- (2- (4-methylpiperazin-1-yl) nicotinoyl) -3- (6- (pentyloxy) pyridin-3-yl) thiourea; 1- (2- (4-methylpiperazin-1-yl) nicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (3-methyl-4- (pentyloxy) phenyl) -3- (2- (4-methylpiperazin-1-yl) nicotinoyl) thiourea; 1- (2-hydroxynicotinoyl) -3- (3-phenoxyphenyl) thiourea; 1- (2-hydroxynicotinoyl) -3- (4- (pentyloxy) phenyl) thiourea; 1- (2-hydroxynicotinoyl) -3- (4-pentylphenyl) thiourea; 1- (3-fluoro-4- (pentyloxy) phenyl) -3- (2-hydroxynicotinoyl) thiourea; 1- (2-hydroxynicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (2-hydroxynicotinoyl) -3- (4- (piperidin-1-yl) -3- (trifluoromethyl) phenyl) thiourea; 1- (4- (methyl (pentyl) amino) -3- (trifluoromethyl) phenyl) -3-nicotinoylthiourea; 1- (3-hydroxynicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (3-hydroxynicotinoyl) -3- (3-phenoxyphenyl) thiourea; 1- (3-fluoro-4- (pentyloxy) phenyl) -3- (3-hydroxynicotinoyl) thiourea; 1- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) -3- (pyrazolo [1,5-a] pyrimidine-6-carbonyl) thiourea; 1- (4- (pentyloxy) phenyl) -3- (pyrazolo [1,5-a] pyrimidine-6-carbonyl) thiourea; 1- (4-pentylphenyl) -3- (pyrazolo [1,5-a] pyrimidine-6-carbonyl) thiourea; 1- (3-phenoxyphenyl) -3- (pyrazolo [1,5- a] pyrimidine-6-carbonyl) thiourea; 1- (6- (pentyloxy) pyridin-3-yl) -3- (pyrazolo [1,5-a] pyrimidine-6-carbonyl) thiourea; 1- (3-Fluoro-4- (pentyloxy) phenyl) -3- (pyrazolo [1,5-a] pyrimidine-6-carbonyl) thiourea; 1- (2- (morpholine-4-carbonyl) nicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (2- (morpholine-4-carbonyl) nicotinoyl) -3- (3-phenoxyphenyl) thiourea; 1- (2 - ((dimethylamino) methyl) nicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1- (2-acetamidonicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; (5 - ((3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thioureido) carbonyl) pyridin-2-yl) methyl acetate; 1- (2- (hydroxymethyl) nicotinoyl) -3- (4- (pentyloxy) -3- (trifluoromethyl) phenyl) thiourea; 1-nicot |
| priorityDate | 2004-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 375.