http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-049420-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-42 |
| filingDate | 2005-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-049420-A1 |
| titleOfInvention | REPLACED PIRAZOLS |
| abstract | This is about substituted pyrazoles, compositions comprising such compounds, methods for their synthesis and their use as parasiticides. Claim 1: A compound of formula (1) or a pharmaceutical, veterinary or agriculturally acceptable salt or solvate thereof, wherein: R 1 represents phenyl or heteroaryl, optionally substituted with one or more groups independently selected from halo, cyano, hydroxy, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkanoyl, C1-6 haloalkanoyl, -S (O) C1-6alkyl, -S (O) C1-6haloalkyl and pentafluorotium; R 2 represents H, halo, cyano, nitro, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 haloalkenyl, C 2-6 alkynyl, C 2-6 haloalkynyl, - S (O) C 1-6 alkyl -S (O) C1-6 nhaloalkyl, - (C0-3 alkylene) -C3-8 cycloalkyl, C1-6 alkanoyl, optionally substituted with C1-6 alkoxy, C1-6 haloalkanoyl, optionally substituted with C1-6 alkoxy, phenyl , het, - (C0-3 alkylene) -N (Ra) Rb, - (C0-3 alkylene) -C (O) NRaRb or - (C0-3 alkylene) -N (Rc) C (O) R6; R3 represents C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 haloalkenyl, - (C0-3 alkylene) -C3-8 cycloalkyl, - (C1-3 alkylene) -S (O) C1- alkyl 6, - (C1-3 alkylene) -S (O) C1-6 nhaloalkyl, - (C0-3 alkylene) -N (Ra) Rb, - (C0-3 alkylene) -phenyl, - (C0-3 alkylene) -het, - (C2-3 alkenylene) -phenyl, - (C2-3 alkenylene) -het, C1-6 alkanoyl, C1-6 haloalkanoyl or -N (Rc) CO2R6; R4 represents H, C1-6 alkyl, C1-6 haloalkyl, - (C0-3 alkylene) -R7 or - (C1-3 alkylene) -R8; or R3 and R4 taken together with the N and S atoms to which they are attached form a 4- to 7-membered ring; R5 represents H, hydroxy, halo, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 haloalkenyl, C1-6 alkoxy, C1-6 haloalkoxy, -N = C (R10) (C0-5 alkylene ) -R11 or -N (R12) R13; R 6 represents C 1-6 alkyl or C 1-6 haloalkyl; R7 represents C3-8 cycloalkyl, -S (O) nR9, phenyl, het, -CO2R6 or C (O) N (Ra) Rb; R8 represents hydroxy, C1-6 alkoxy, C1-6 haloalkoxy, cyano, - N (Ra) Rb or -O-C (O) R6; R9 represents C1-6 alkyl, C1-6 haloalkyl, C3-8 cycloalkyl, -N (Ra) Rb, phenyl or het; R10 represents H, C1-6 alkyl or C1-6 haloalkyl; R11 represents H, hydroxy, C1-3 alkoxy, -N (Ra) Rb, phenyl, het or C3-8 cycloalkyl, with the proviso that -N = C (R10) (C0-5 alkylene) -R11 is not - N = CH2; R 12 represents H, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkenyl or C 1-6 haloalkenyl; R13 represents H, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkenyl, C1-6 haloalkenyl, C3-8 cycloalkyl, phenyl, het, - (C1-6 alkylene) -R14, -C (O) pR15 or -CON (R16) (C1-6 rent) -R17; R14 represents hydroxy, C1-3 alkoxy, C1-3 haloalkoxy, C3-8 cycloalkyl, phenyl, het or -N (Ra) Rb; R 15 represents C 1-6 alkyl, C 1-6 haloalkyl or - (C 1-6 alkylene) -C 1-3 alkoxy; R16 represents H, C1-6 alkyl or C1-6 haloalkyl; R17 represents H or N (Ra) Rb, Ra and Rb independently represent H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl or C2-6 haloalkenyl, or Ra also represents - (C0-3 alkylene) -cycloalkyl C3-8, - (C0-3 alkylene) -phenyl or - (C0-3 alkylene) -het, or Ra and Rb together form a 4- to 7-membered ring, optionally substituted with one or more groups independently selected from halo, hydroxy, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and C 1-6 haloalkoxy; Rc represents H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 haloalkenyl, - (C0-3 alkylene) -C3-8 cycloalkyl, - (C0-3 alkylene) -phenyl or - (alkylene C0-3) -het; n represents an integer selected from 0, 1 and 2; p represents an integer selected between 1 and 2; where het represents a four to seven membered heterocyclic group, which is aromatic or non-aromatic and which contains one or more heteroatoms selected from N, O, S and mixtures thereof; wherein heteroaryl represents a 5 or 6 membered aromatic ring containing 1-3 heteroatoms selected from N, O and S or 4-N atoms to form a tetrazolyl; where both phenyl and het may be optionally substituted, when valence permits, with one or more substituents independently selected from halo, hydroxy, cyano, nitro, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkenyl, C1- haloalkenyl 6, C 1-6 alkoxy, C 1-6 haloalkoxy, C 3-8 cycloalkyl, C 1-6 alkanoyl, C 1-6 haloalkanoyl, C 1-6 alkylcarbonyloxy, C 1-6 alkoxycarbonyl and NRaRb; wherein C3-8 cycloalkyl may be optionally substituted with one or more groups independently selected from halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkenyl, C1-6 haloalkenyl, hydroxy, C1-6 alkoxy and C1-6 haloalkoxy ; and where any alkylene or alkenylene group may be optionally substituted with one or more halo. |
| priorityDate | 2004-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 30.