http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-047975-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1542e8802a0e6a7a8a7c6bd5627eb857 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4406 |
| filingDate | 2005-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-047975-A1 |
| titleOfInvention | KV1.5 BLOCKERS TO SELECTIVELY INCREASE HEADPHONE CONTRACTILITY AND TREAT CARDIAC INSUFFICIENCY |
| abstract | Claim 1: The use of compounds of the formulas (1) and / or (2), and / or their physiologically tolerated salts to produce a drug for the therapy or prophylaxis of heart failure, in which the meanings are: R1 is alkyl having 3, 4 or 5 C atoms or quinolinyl, R2 is alkyl having 1, 2, 3, or 4 C atoms or cyclopropyl; R3 is phenyl or pyridyl, in which phenyl and pyridinyl are not substituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, CF3, OCF3, alkyl having 1, 2, or 3 C atoms and alkoxy having 1, 2 or 3 C atoms; A is -CnH2n-; n is 0, 1 or 2; R4, R5, R6, and R7 are independently from each other hydrogen, F, Cl, CF3, OCF3, CN, alkyl having 1, 2 or 3 C atoms, alkoxy having 1, 2 or 3 C atoms; B is -CmH2m-; m is 1 or 2; R8 is alkyl having 2 or 3 C atoms, phenyl or pyridyl, in which phenyl and pyridyl are not substituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, CF3, OCF3, alkyl having 1, 2 or 3 C atoms and alkoxy having 1, 2 or 3 C atoms; R9 is C (O) OR10 or COR10; R10 is -CxH2x-R11; x is 0, 1 or 2; R11 is phenyl, in which the phenyl is unsubstituted or substituted with 1 or 2 substituents selected from the group consisting of F, Cl, CF3, OCF3, alkyl having 1, 2, or 3 C atoms and alkoxy having 1, 2 or 3 C atoms. Claim 5: The composition comprising the compounds of formulas (1) and / or (2), and / or one of its physiologically tolerated salts according to claim 1, for producing a medicament for the therapy or prophylaxis of heart failure, in which the compounds of formulas (1) and / or (2) are selected from the group of N- (2-pyridin-3-ylethyl) -2 '- {[ 2- (4-methoxyphenyl) acetylamino] methyl} biphenyl-2-carboxamide; N- (2- (2-pyridyl) ethyl) -2 '- (benzyloxycarbonylaminomethyl) biphenyl-2-carboxamide; N- (2,4-difluorobenzyl) -2 '- {[2- (4-methoxyphenyl) acetylamino] methyl} -biphenyl-2-carboxamide; N- (2- (2-pyridyl) ethyl) - (S) -2 '- (a-methylbenzyloxycarbonylaminomethyl) biphenyl-2-carboxamide; 2- (butyl-1-sulfonylamino) -N- [1 (R) - (6-methoxypyridin-3-yl) propyl] benzamide; 2- (butyl-1-sulfonylamino) -N- (cyclopropylpyridin-3-ylmethyl) -5-methyl-benzamide; (S) -5-Fluoro-2- (quinoline-8-sulfonylamino) -N- (1-phenylpropyl) benzamide and / or its physiologically tolerated salts. |
| priorityDate | 2004-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 27.