http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-047969-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2005-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2006-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-047969-A1 |
| titleOfInvention | PIRAZOLOTRIAZINAS AS QUINASA INHIBITORS |
| abstract | This refers to pyrazolotriazines as kinase inhibitors, methods of preparing said compounds; pharmaceutical compositions containing them and uses. Claim 1: A compound represented by structural formula (1) or a pharmaceutically acceptable salt, solvate or ester of said compound, wherein: R1 is selected from the group consisting of H, alkyl, aryl, heteroaryl, heteroarylalkyl, arylalkyl, NR6R7 , cycloalkyl and cycloalkylalkyl, wherein each of said alkyl, aryl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl and arylalkyl may be unsubstituted or optionally substituted independently with one or more portions, the same or different, wherein each is selected independently of the group consisting of halo, alkyl, aryl, heteroaryl, heterocyclyl, trifluoromethyl, OR6, NR6R7, SR6, SO2R6, .CN, SO2N (R6R7) and NO2; R2 is alkyl, cycloalkyl, alkenyl, alkynyl, trifluoromethyl, -OR7, - SR7, hydroxyalkyl, haloalkyl, aryl, heteroaryl, halo, CN, formyl, nitro, alkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, or -alkylene-N (R8R9), ( where R8 and R9 independently represent H or alkyl, or R8 and R9 taken together with N in -N (R8R9) form a 5- to 7-membered heterocycle); R3 is -NR4R5, or as shown in the group of formulas (2), H, alkyl, alkylthio, aralkylthio, alkylsulfinyl, or aralkylsulfinyl; R4 is alkyl, cycloalkyl or heterocyclyl, wherein each of said alkyl, cycloalkyl and heterocyclyl can be unsubstituted or optionally substituted independently with 1 to 4 substituents, the same or different, wherein each substituent is independently selected from the group consisting of halo, alkyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, trifluoromethyl, OR6, NR6R7, SR6, SO2R6, CN, SO2N (R6R7) and NO2; R5 is H, alkyl, aryl, heteroaryl, arylalkyl, cycloalkyl, heterocyclyl, acyl, or heteroarylalkyl; R6 is H, alkyl or aryl; R7 is H or alkyl; R10 is halo, alkyl, hydroxyalkyl, trifluoromethyl, OR6, NR6R7, SR6, SO2R6, CN, SO2N (R6R7) or NO2; and n is 0 to 4, and when n is 2 to 4, the portions n can be the same or different, where each is independently selected; with the following conditions: (1) that when R2 is C1-4 alkyl and R5 is H, then R4 is not a C1-4 alkyl; (2) that when R2 is halo, CN, formyl, nitro, alkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, or -alkylene-N (R8R9), then: (a) R3 is not H, alkylthio, aralkylthio, alkylsulfinyl, aralkylsulfinyl, or - NR4R5; and (b) n is not 0; and (3) that when R2 is alkyl, cycloalkyl, alkenyl or alkynyl, then R3 is not NH (methyl), N, N (dimethyl), NH (acetyl) or N (methyl) (acetyl). |
| priorityDate | 2004-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.