http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-046992-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-403 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 |
| filingDate | 2004-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60f7f67b7b46dcab616964d18a30ad8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fc312ddecea05805b3ba11d3c61a169 |
| publicationDate | 2006-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-046992-A1 |
| titleOfInvention | DERIVATIVES OF ESPIRO-DIHIDROBENZOFURANOS |
| abstract | This refers to spiro dihydrobenzofuran derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. Claim 1: A compound characterized in that it responds to formula (1) wherein m is 0, 1, 2, 3 or 4, wherein each R1 independently represents halogen, cyano, hydroxyl, C1-6 alkyl, C1-6 haloalkyl, C1 alkoxy -6, C1-6 alkylsulfonyl or sulfonamido (-SO2NH2); X represents a union or -CH2- and Y represents a union or -CH2-, as long as X and Y both do not simultaneously represent a union or -CH2-; n is 0, 1 or 2; where each R2 independently represents halogen, C1-6 alkyl or C1-6 haloalkyl; q is 0 or 1; p is 0 or 2; R3 represents a group selected from halogen, NR6R7, carboxyl or C1-6 alkyl wherein said C1-6 alkyl group is optionally substituted by one or more of halogen, amino, hydroxyl, C1-6 alkoxy, N- (C1-6alkyl ) amino, N, N-di- (C1-6 alkyl) amino, carboxy or carbamoyl; R4 represents H, C1-6 alkyl, C1-6 haloalkyl or halogen; t is 0, 1 or 2, as long as p and t are not both 0; R5 represents a saturated or unsaturated ring system of between 5 and 10 members where said ring system can comprise at least one heteroatom in the ring selected from N, O and S, where the ring system is optionally substituted with one or more substituents that are independently selected from halogen, cyano, oxo, nitro, hydroxyl, carboxyl, -C (O) H, -NR8R9, -C (O) NR10R11, -NHC (O) R12, -NHSO2R13, -SO2NR14R15, -NHC (O) NR16R17, a group selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkenyl, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkylsulfonyl, C 1-6 haloalkyl, C 1-6 alkylcarbonyl - 6, phenylcarbonyl, C3-6 cycloalkyl, phenyl and a saturated or unsaturated 5 or 6 membered heterocyclic ring comprising at least one heteroatom in the ring selected from N, O and S, where each group is optionally substituted with one or more substituents that are independently selected from halogen, cyano, hydroxyl, carboxyl, C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 alkoxy and C 1-6 alkoxycarbonyl, R 6 and R 7 each independently represent H or a group selected from C 1-6 alkyl and C 1-6 alkylcarbonyl, each of which it may be optionally substituted with one or more substituents that are selected from halogen, amino, hydroxyl, C1-6 alkoxy, N- (C1-6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, carboxy, carbamoyl or C1-6 alkoxycarbonyl, or R6 and R7 together with the N atom to which they are attached form a saturated 4- to 7-membered heterocyclic ring that may be optionally substituted with one or more substituents that are selected from halogen, amino, hydroxy, C1-6 alkoxy, N- (C1-6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, carboxy, carbamoyl or C1-6 alkoxycarbonyl; R8, R9, R10, R11 each independently represent H or a group that is selected from C1-6 alkyl or C3-6 cycloalkyl, where each group is optionally substituted with one or more substituents that are independently selected from halogen, amino, hydroxyl , C1-6 alkoxy, N- (C1-6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, carboxy or carbamoyl; or R10 and R11, together with the N atom to which they are attached, form a saturated 4- to 7-membered heterocyclic ring that may be optionally substituted with at least one substituent selected from halogen, amino, hydroxyl, C1 alkoxy -6, N- (C1-6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, carboxy, or carbamoyl; R12 represents H or a group selected from C1-6 alkyl or C3-6 cycloalkyl where each group is optionally substituted with one or more substituents that are independently selected from halogen, amino, hydroxyl, C1-6 alkoxy, N- (C1 -6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, carboxy, or carbamoyl; R13 represents a group selected from C1-6 alkyl or C3-6 cycloalkyl, where each group is optionally substituted with one or more substituents that are independently selected from halogen, amino, hydroxyl, C1-6 alkoxy, N- (C1- 6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, carboxy, or carbamoyl; R14, R15, R16 and R17 each independently represent H or a group that is selected from C1-6 alkyl or C3-6 cycloalkyl, where each group is optionally substituted with one or more substituents that are independently selected from halogen, amino, hydroxyl , C1-6 alkoxy, N- (C1-6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, carboxy, or carbamoyl; or R14 and R15, or R16 and R17 together with the N atom to which they are each independently forms a saturated 4- to 7-membered heterocyclic ring that may be optionally substituted with at least one substituent selected from halogen, amino, hydroxy, C1-6 alkoxy, N- (C1-6 alkyl) amino, N, N-di- (C1-6 alkyl) amino, carboxy, or carbamoyl; or a salt or solvate thereof acceptable for pharmaceutical use. |
| priorityDate | 2003-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.