http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-046784-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0075 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-452 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 |
| filingDate | 2004-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-046784-A1 |
| titleOfInvention | COMPOUND OF CYCLINE AMINE PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE TO PREPARE THIS LAST |
| abstract | A cyclic amine compound having the formula (1), in which: when X and Y carbons, n is 0, 1, 2 or 3; m is 1, 2, or 3; p is 0, 1 or 2; when X is oxygen and Y is carbon, n is 1; m is 2; and p is 1; when X is carbon and Y is nitrogen, n is 2; m is 1; and p is 2; W is O, S, or NH; U is NR3, O, or a link; R3 is selected from the group consisting of hydrogen, branched or unbranched C1-8 alkyl, C3-8 cycloalkyl, (C3-8) cycloalkyl-lower alkyl, substituted or unsubstituted phenyl, or substituted or unsubstituted phenyl (C1-3 ) lower alkyl; where, when substituted, a group is substituted with one or more radicals selected from the group consisting of C1-8 alkoxy, halo, hydroxy, amino, cyano, trifluoromethyl, branched or unbranched C1-8 alkyl, C3-8 cycloalkyl and C3-8 cycloalkyl-lower alkyl; q is an integer from 0 to 7; h is 0, 1, or 2; g is 1, 2, or 3; V is selected from the group consisting of phenyl, thiophenyl, furanyl, pyridinyl, naphthyl, quinolinyl, indolyl, benzothiophenyl, and benzofuranyl; R4 is selected from the group consisting of hydrogen, hydroxy, amino, halo, cyano, trifluoromethyl, C1-8 alkoxy, branched or unbranched C1-8 alkyl, C3-8 cycloalkyl, cycloalkyl (C3-8) lower alkyl, phenyl, lower phenylalkyl (C1-3), COR6, COOR6, CONHR6, CON (R6) 2, NHR6, N (R6) 2, and G; k is an integer from 0 to 5; T is selected from the group consisting of one of the following substituted or unsubstituted groups: phenyl, mono, di, and tri substituted, thiophenyl, furanyl, pyridinyl, naphthyl, quinolinyl, indolyl, benzothiophenyl, pyrrole, thiazole, imidazole, pyrazole, triazole, oxazole, isoxazole, furacan, benzofuranyl, isoindole, indazole, carbazole, benzimidazole, indolizine, purine, adenine, guanine, xanthine, caffeine, uric acid, azepine, pyridine, pyridazine, pyrazine, pyrimidine, triazine, pyrimidone, pyrimidone , thymine, isoquinoline, phthalazine, pteridine, naphthyridine, acridine, cinoline, phenazine, quinazoline, phenoxazine, quinoxaline, phenothiazine; where, when substituted, a group is substituted with one more radical selected from the group consisting of C1-8 alkoxy, halo, hydroxy, amino, trifluoromethyl, branched or unbranched C1-8 alkyl, C3-8 cycloalkyl, C3-cycloalkyl -8) lower alkyl, phenyl and phenyl (C1-3) lower alkyl; R5 is selected from the group consisting of COOR6, CONHR6, COR6, CON (R6) 2, COG, substituted or unsubstituted oxadiazolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted imidazolyl, substituted or unsubstituted phenoxy, or cyano; where, when substituted, a group is substituted with one or more radicals selected from the group consisting of branched or unbranched C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl, lower alkyl, phenyl and lower (C 1 -C) alkyl -3), C1-8 alkoxy, halo, hydroxy, amino, cyano and trifluoromethyl; G is selected from the group consisting of one of the following substituted or unsubstituted group; pyrrolidinyl, piperidinyl, dihydroindolyl, tetrohydroquinolinyl, morpholino, azetidinyl, hexahydroazepinyl, or octahydroazocinyl; where when substituted, a group is substituted with one or more radicals selected from the group consisting of C1-8 alkoxy, hydroxy, amino, C1-8 alkyl, branched or unbranched, C3-8 cycloalkyl, cycloalkyl (C3-8) - lower alkyl, phenyl and phenyl (C1-3) lower alkyl; and R1 is selected from the group consisting of one of the following substituted or unsubstituted groups: hydrogen, phenyl, lower phenylalkyl (C1-6), thiophenyl, thiophenyl lower alkyl (C1-6), furanyl, furanyl-lower alkyl (C1- 6), pyridinyl, pyridinyl-lower alkyl (C1-6), imidazolyl, imidazolyl-lower alkyl (C1-6), naphthyl, naphthyl-lower alkyl (C1-6), quinolinyl, quinolinyl-lower alkyl (C1-3) , indolyl, indolyl-lower alkyl (C1-6), benzothiophenyl, benzothiophenyl-lower alkyl (C1-6), benzofuranyl, benzofuranyl-lower alkyl (C1-6), benzoimidazolyl, benzoimidazolyl-lower alkyl (C1-6), alkyl C1-8 branched or unbranched, C3-8 cycloalkyl, C3-8 cycloalkyl-lower (C1-6) alkyl, or C3-8 alkenyl; where, when substituted, a group is substituted with one or more radicals selected from the group consisting of C1-8 alkoxy, phenoxy, phenylalkoxy (C1-3), halo, hydroxy, amino, cyano, trifluoromethyl, methylenedioxy, ethylenedioxy, propylenedioxy , butylenedioxy, branched or unbranched C 1-8 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl, lower alkyl, phenyl, phenyl (C 1-3) lower thiophenyl, thiophenyl-lower (C 1-3) alkyl, furanyl, furanyl lower alkyl (C1-3), pyridinyl, pyridinyl lower alkyl (C1-3), naphthyl, naphthyl lower alkyl (C1-3) quinolinyl, quinolinyl lower alkyl (C1-3), indolyl, indolyl lower alkyl (C1-3), benzothiophenyl, benzothiophenyl-lower alkyl (C1-3), benzofuranyl, benzofuranyl-lower alkyl (C1-3), COOH, COR6, COOR6, CONHR6, CON (R6) 2, COG, NHR6, N ( R6) 2, G, OCOR6, OCONHR6, NHCOR6, N (R6) COR6, NHCOOR6 and NHCONHR6; or a pharmaceutically acceptable salt. Pharmaceutical composition for the treatment of diseases mediated by the muscarinic acetylcholine receptor, comprising a compound of the formula (1) and a pharmaceutically acceptable carrier thereof. Use of a compound of the formula (1) to prepare a pharmaceutical composition to inhibit the binding of acetylcholine to its receptors in a mammal in need thereof, being preferably effective to treat a disease mediated by the muscarinic acetylcholine receptor, in which acetylcholine binds to said receptor. The disease can be chronic obstructive pulmonary disease, chronic bronchitis, asthma, chronic respiratory obstruction, pulmonary fibrosis, pulmonary emphysema and allergic rhinitis. |
| priorityDate | 2003-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.