http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-046449-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d15c8aa94f15f95f4711eac406699a3a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 |
| filingDate | 2004-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aeb6da4a5ecc900c0caa3227ee5a5b2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca2c4abfce131441ad785bc8d59375b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c95f38383d9b3923b4cd6320f7cbdf20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fae1a1662d600cd6a76ef19ee0471504 |
| publicationDate | 2005-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-046449-A1 |
| titleOfInvention | DUAL MOLECULES CONTAINING A PEROXIDIC DERIVATIVE, ITS SYNTHESIS AND ITS THERAPEUTIC APPLICATIONS |
| abstract | Preparation and application procedure as antimalarial activity medications. Claim 1: Compound that responds to formula (1) in which: A represents a molecule residue of antimalarial activity and / or a residue that facilitates bioavailability; p, p ', p' 'represent, independently of each other, 0 or 1, and at least one, po p' 'is equal to 1, Y1 and Y2, identical or different, represent a linear C1-6 alkylene chain, branched or cyclic comprising, optionally, one or more amine, amide, thioamide, sulfonyl, sulfonate, sulfonamide, carbonyl, thiocarbonyl, carboxyl, thiocarboxyl, ether or thioether radicals; this alkylene chain is optionally substituted by one or more groups chosen from halogen atoms, hydroxyl groups, acetal groups and C1-5 alkyl radicals, linear, branched or cyclic; U represents an amine, amide, thioamide, sulfonyl, sulfonate, sulfonamide, carbonyl, thiocarbonyl, carboxyl, thiocarboxyl, ether or thioether radical; Z1 and Z2, identical or different, represent a linear, branched or cyclic, saturated or unsaturated C1-4 alkylene radical, Z1 or Z2, one of them, may be absent, or the set Z1 + Z2 represents a polycyclic structure that includes N and C junction Cj; R1 and R2, identical or different, represent an atom of H or a functional group capable of increasing the water solubility of the dual molecule; Rx and Ry together form a cyclic peroxide comprising 4 to 8 links and having 1 or 2 additional O atoms in the cyclic structure, and Cj is one of the peaks of that cyclic peroxide; said cyclic peroxide is substituted by 1 to 8 R3 groups, identical or different from each other, which occupy any position on the C atoms of the peroxy cycle and are chosen from the following atoms and groups: H, halogen, -OH, -CF3, -NO2, aryl or heteroaryl, alkyl or -O-alkyl and said alkyl groups comprise 1 to 10 C atoms and are linear, branched or cyclic, or mono-, bi- or tricyclic structure of C3 to C18 which may also contain 1 or several heteroatoms chosen from O, N and S, optionally substituted by one or more groups chosen from halogen atoms, hydroxyl groups and C1-6 alkyl groups, linear, branched or cyclic; at least one of the groups R3 is different from an atom of H; two R3 groups carried by adjacent C atoms in the peroxy cycle, which may together form a cyclic structure of 5 or 6 links, saturated or unsaturated, optionally substituted in any position by one or more R3 substituents as defined above; two R3 groups carried by the same C atom of the peroxy cycle, which can together form a mono-, bi- or tricyclic structure as defined above in the base or addition salt state with an acid, as well as , in a state of hydrate or solvate. |
| priorityDate | 2003-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.