http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-046329-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7d9072cb25d6ae674a3943f14e5771e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 |
| filingDate | 2004-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_634f13787d78f29ce520d691d11cf34c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b811a375026fdda48982b5deb458e70a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ed654ca6731909b86ac3b42c016d20d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_774a7bde46b1171daaefddae859d5718 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75dfca58ec65084790e9bc46609a932b |
| publicationDate | 2005-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-046329-A1 |
| titleOfInvention | CHEMIOKIN INHIBITING PIPERAZINE DERIVATIVES AND THEIR USE TO TREAT MYOCARDITIS |
| abstract | Piperazine derivatives of formulas (1), (2), (3) and (4), and their use to treat myocarditis, enantiomers, diastereomers and salts acceptable for pharmaceutical use thereof, where R1a is one or more substituents independently selected from the group consisting of oxo, halo, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkylaminoalkyl, (cycloalkylalkyl) aminoalkyl, haloalkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, formyl, formylalkyl, hydroxyalkyl, hydroxyalkenyl aralkyl, (hydroxy) cycloalkylalkyl, mercaptoalkyl, cyanoalkyl, haloalquilcarbonilaminoalquilo, (alkoxy) aralkyl, alkoxyalkyl, aryloxyalkyl, aralkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, hydroxyalkylthioalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, monoarilaminoalquilo, monoaralquilaminoalquilo, alkylcarbonylaminoalkyl, (alkylcarbonyl) (alkyl) aminoalkyl, azidoalkyl, ur eidoalquilo, monoalquilureidoalquilo, dialquilureidoalquilo, (alkoxycarbonylalkyl) ureidoalkyl, alkoxycarbonylaminoalkyl, hydroxyalkylaminoalkyl, ariloxialquilcarboniloxialquilo, alcoxialquilcarboniloxialquilo, aralcoxialquilcarboniloxialquilo, alkylcarbonyl, alkylcarbonylalkyl, carboxy, alkoxycarbonyl, aralkoxycarbonyl, aralkylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, monoarilaminocarbonilo, monoaralquilaminocarbonilo, carboxyalkyl, alkoxycarbonylalkyl, aralkoxycarbonylalkyl, aminocarbonylalkyl , monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, monoarylaminocarbonylalkyl, monoaralkylaminocarbonylalkyl, arylsulfonyl, heterocyclyl and heterocyclylalkyl; R2 is one or more substituents independently selected from the group consisting of hydrogen, hydroxy, hydroxysulfonyl, halo, alkyl, mercapto, mercaptoalkyl, alkylthiol, alkylsulfinyl, alkylsufonyl, alkylthioalkyl, alkylsulphinyl alkyl, alkylsulfonylalkyl, alkoxy, aryloxy, haloalkyl, formyl, formyl, formyl , nitrous, cyano, aralkoxyl, haloalkoxy, cycloalkyl, cycloalkylalkyl, (hydroxy) cycloalkylalkyl, cycloalkylamino, cycloalkylaminoalkyl, (cycloalkylalkyl) amino, (cycloalkylalkyl) aminoalkyl, cyanoalkyl, alkenyl, alkynyl, aryl, hydroxyalkylalkyl , hydroxyalkylthioalkyl, hydroxyalkenyl, hydroxyalkynyl, alkoxyalkyl, (alkoxy) aralkyl, aryloxyalkyl, aralkoxyalkyl, amino, monoalkylamino, dialkylamino, monoarylamino, monoaralkylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkylalkyl, alkylaminoalkylalkyl, alkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylaminoalkylalkyl carbonylamino, (alkylcarbonyl) (alkyl) amino, alkylcarbonylaminoalkyl, (alkylcarbonyl) (alkyl) aminoalkyl, alkoxycarbonylamino, (alkoxycarbonyl) (alkyl) amino, alkoxycarbonylaminoalkyl, (alkoxycarbonyl) (alkyl) aminoalkyl, carboxycarbonyl, alkylalkylcarbonyl, alkylalkylcarbonyl, alkylalkylcarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl, alkoxycarbonyl arylcarbonyl, arylcarbonylalkyl, aralkylcarbonyl, aralquilcarbonilalquilo, carboxyalkyl, alkoxycarbonylalkyl, aralkoxycarbonylalkyl, alcoxialquilcarboniloxialquilo, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, monoarilaminocarbonilo, monoaralquilaminocarbonilo, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, monoarilaminocarbonilalquilo, monoaralquilaminocarbonilalquilo, amidino, guanidino, ureido, monoalquilureido, dialkylureido, ureidoalkyl, monoalquilureidoalquilo, dialkylureidoalkyl, herocyclyl, and heterocyclylalkyl; R3 is a carbocyclic ring system substituted by one or more substituents independently selected from the group consisting of hydrogen, hydroxyl, hydroxysulfonyl, halo, alkyl, mercapto, mercaptoalkyl, alkylthiol, alkylsulfinyl, alkylsulfonyl, arylsulfonyl, alkylthioalkyl, alkylsulfinyl alkyl, alkylsulfonylalkyl, alkylsulfonylalkyl, alkylsulfonylalkyl hydroxyalkoxy, aryloxy, haloalkyl, formyl, formylalkyl, nitro, nitroso, cyano, aralkoxy, haloalkoxy, aminoalkoxy, cycloalkyl, cycloalkylalkyl, (hydroxy) cycloalkylalkyl, cycloalkylamino, cycloalkylaminoalkyl, cyanoalkylalkyl, alkenyl, alkyloralkyl, alkenyl, alkyloralkyl, alkenyl, alkyloralkyl, alkenyl, alkylalkyl, alkenyl, alkyl hydroxy) aralkyl, (monoalkylamino) aralkyl, (hydroxyalkyl) thioalkyl, hydroxyalkenyl, hydroxyalkynyl, alkoxyalkyl, (alkoxy) aralkyl, aryloxyalkyl, aralkoxyalkyl, amino, monoalkylamino, dialkylamino, monoarylamino, monoaralkylamino, aminoalkylaminoalkyl, aminoalkylaminoalkyl, aminoalkylaminoalkyl, aminoalkylaminoalkylamino, amino lcarbonilamino, alkoxycarbonylamino, alkenylcarbonylamino, cycloalkylcarbonylamino, arylcarbonylamino, heterocyclylcarbonylamino, haloalkylcarbonylamino, alkoxyalkylcarbonylamino, alcoxicarbonilalquilcarbonilamino, (alkylcarbonyl) (alkyl) amino, (alkoxycarbonyl) (alkyl) amino, alkylsulfonylamino, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, hydroxyalkylaminoalkyl, monoarilaminoalquilo, monoaralquilaminoalquilo, alkylcarbonylaminoalkyl, arylcarbonylaminoalkyl, (alkylcarbonyl) (alkyl) aminoalkyl, (cycloalkylalkyl) aminoalkyl, alkoxycarbonylaminoalkyl, alcoxicarbonilalquilcarbonilaminoalquilo, (alkoxycarbonyl) (alkyl) aminoalkyl, alkylsulfonylaminoalkyl, (alkylsulfonyl) (alkyl) aminoalkyl, arylsulphonylaminoalkyl, (arylsulfonyl) (alkyl) aminoalkyl, heterocicliloaminoalquilo, carboxyl , alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, (hydroxyalkoxy) carbonyl, carboxyalkyl, alkoxycarbonylalkyl, aralkoxycarb onilalquilo, alcoxialquilcarboniloxialquilo, dialquilaminocarboniloxialquilo, alkylcarbonylalkyl, arylcarbonylalkyl, aralquilcarbonilalquilo, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, monoarilaminocarbonilo, monoaralquilaminocarbonilo, (aminocarbonyl) aminocarbonyl, (monoalquilaminocarbonilalquil) aminocarbonyl, (carboxyalkyl) aminocarbonyl, (alkoxycarbonylalkyl) aminocarbonyl, (aminoalkyl) aminocarbonyl, (hydroxyalkyl) aminocarbonyl, aminocarbonyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, monoarilaminocarbonilalquilo, monoaralquilaminocarbonilalquilo, amidino, hydroxyamidino, guanidino, ureido, monoalquilureido, monoarilureido, monoaralquilureido, monohaloalquilureido, (monoalkyl) (monoaryl) ureido, dialkylureido, diarilureido, (haloalquilcarbonil) ureido, ureidoalkyl, monoalquilureidoalquilo, dialquilureidoalquilo , monoarylureidoalkyl, monoaralkylureidoalkyl, monohaloalkylureidoalkyl, (haloalkyl) (alkyl) urei doalquilo, (alkoxycarbonylalkyl) ureidoalkyl, glycinamido, monoalquilglicinamido, aminocarbonilglicinamido, (alcoxialquilcarbonil) glycinamido, (aminocarbonyl) (alkyl) glycinamido, (alcoxicarbonilalquilcarbonil) (alkyl) glycinamido, (alcoxicarbonilaminoalquilcarbonil) I glycinamido, arilcarbonilglicinamido, (arylcarbonyl) (alkyl) glycinamido, ( monoaralkylaminocarbonyl) glycinamide, (monoaralkylaminocarbonyl) (alkyl) glycinamide, (monoarylaminocarbonyl) glycinamide, (monoarylaminocarbonyl) (alkyl) glycinamide, glycinamidoalkyl, alaninamide, monoalkylalanamido, alanine allyl alkylalkyl; or R3 is a carbocyclic ring system substituted by one or more substituents independently selected from the group consisting of hydrogen, hydroxyl, halo, alkyl, alkylsulfonyl, arylsulfonyl, alkoxy, hydroxyalkoxy, haloalkyl, formyl, nitro, cyano, haloalkoxy, alkenyl, alkynyl , aryl, aralkyl, amino, monoalkylamino, dialkylamino, monoarylamino, monoaralquilamino, alkylcarbonylamino, alkoxycarbonylamino, alkenylcarbonylamino, cycloalkylcarbonylamino, arylcarbonylamino, haloalkylcarbonylamino, alkoxyalkylcarbonylamino, alcoxicarbonilalquilcarbonilamino, (alkylcarbonyl) (alkyl) amino, (alkoxycarbonyl) (alkyl) amino, alkylsulfonylamino, aminoalkyl , monoalkylaminoalkyl, dialkylaminoalkyl, alkylcarbonylaminoalkyl, arylcarbonylaminoalkyl, (alkylcarbonyl) (alkyl) aminoalkyl, alkoxycarbonylaminoalkyl, carboxyl, alkoxycarbonyl, aralkoxycarbonyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl monoalkylcarbonyl yl, dialkylaminocarbonyl, monoarylaminocarbonyl, aminocarbonylalkyl, monoalkylaminocarbonylalkyl, dialkylaminocarbonylalkyl, monoarylaminocarbonylalkyl, guanidino, ureido, monoalkylureido, ureidoalkyl, monoalkylureidoalkyl, and glycinamide; R4 is -O-, -NH (R7) -, -C (R8) 2- or a bond; R5 is an alkylene chain or an alkylidene chain, or if R4 is a bond, R5 is an alkylidene chain optionally substituted by aryl or -N (R7) 2; R6 is -C (O) -, -C (S ) -, -CH2- or a link; each R7 is independently selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, alkylcarbonyl, alkylcarbonylalkyl, aralkylcarbonyl, aralkylcarbonylalkyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl and alkoxycarbonyl; and each R8 is independently selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, hydroxyl, alkoxyl, hydroxyalkyl, alkoxyalkyl, amino, monoalkylamino, dialkylamino, alkylcarbonylamino, cycloalkylcarbonylamino, cicloalquilalquilcarbonilamino, alkoxycarbonylamino, alkylsulfonylamino, arylcarbonylamino, alcoxicarbonilalquilcarbonilamino, (alkylcarbonyl) (alkyl) amino, aralkylcarbonylamino, (aralkylcarbonyl) (alkyl) amino, alkylcarbonylaminoalkyl, cicloalquilcarbonilaminoalquilo, alkoxycarbonylaminoalkyl, (alkylcarbonyl) (alkyl) aminoalkyl, aralquilcarbonilaminoalquilo, heterocyclylcarbonylaminoalkyl, (aralkylcarbonyl) (alkyl) aminoalkyl, arylsulfonylamino, alkylsulfonylaminoalkyl, ureido, monoalquilureido, monohaloalquilureido , dialkylureido, ureidoalkyl, monoalkylureidoalkyl, dialkylureidoalkyl, monohaloalkylureidoalkyl, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, c |
| priorityDate | 2003-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 49.