http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-046056-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2004-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73a326ebaa26768377d908b398975b6e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad0dd991d74d965662381a2fbec240e3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04683e2f9602db782c20769f123af5e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90ab3a23054b339e0c10476d0a112b84 |
| publicationDate | 2005-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-046056-A1 |
| titleOfInvention | DERIVATIVES OF THIOPHEN-2-CARBOXAMIDE AND ITS USE AS ANTAGONISTS OF CB1 CANABINOID RECEPTORS |
| abstract | This refers to thiophene-2-carboxamide derivatives and their use as antagonists of CB1 cannabinoid receptors. Procedure for preparation and therapeutic application. Claim 1: Compound that responds to formula (1) in which R 1 represents H or a C 1-4 alkyl; R2 represents a C4-10 alkyl group, a C3-12 non-aromatic carbocyclic radical, not substituted once or several times by a C1-4 alkyl, C1-4 alkoxy or hydroxyl group; a 1,2,3,4-tetrahydronaphthyl-1- or -2; a monooxygenated or mono-sulfur, saturated heterocyclic radical of 5 to 7 atoms, unsubstituted or substituted once or several times by a C1-4 alkyl group; a mononitrogenated, saturated heterocyclic radical of 5 to 7 atoms, where the N atom is substituted by a C1-4 alkyl, phenyl, benzyl, C1-4 alkoxycarbonyl or C1-4 alkanoyl group; a C1-3 alkylene group bearing a C3-10 non-aromatic carbocyclic radical unsubstituted or substituted once or several times by a C1-4 alkyl group; a phenylalkylene group in which the alkylene is C1-3, unsubstituted or substituted in the alkylene by one or more methyl groups, and / or substituted in the phenyl by one or more identical or different substituents chosen from a halogen atom or a C1-4 alkyl group, trifluoromethyl, C1-4 alkoxy, trifluoromethoxy; a methylene substituted by a benzothienyl, benzofuryl, thienyl, or furyl radical, and said radicals are unsubstituted or substituted by one or more C1-4 alkyl groups; an NR9R10 group; or R1 and R2 together with the N atom to which they are attached constitute either a piperazin-1-yl or 1,4-diazepan-1-yl radical substituted in 4- by a phenyl or benzyl group, or a radical piperidin-1-yl or pyrrolidin-1-yl mono- or gem- substituted by a phenyl, benzyl, C1-4 alkyl, hydroxy, C1-4 alkoxy, cyano, C1-3 alkanoyl, C1-4 alkoxycarbonylamino, C1 alkanoylamino -3; the phenyl or benzyl groups are unsubstituted or substituted once or several times by a halogen atom and / or a C1-4 alkyl and / or C1-4 alkoxy group, and / or trifluoromethyl; R3, R4, R5, R6, R7, R8 each independently represent each other an H or halogen atom, a C1-6 alkyl group, C1-6 alkoxy, trifluoromethyl or an S (O) nAlk group; R9 represents an H atom or a methyl group; R10 represents a 1-6 alkyl, phenyl or C3-10 cycloalkyl group, and the phenyl and cycloalkyl groups are unsubstituted or substituted by one or more halogen atoms and / or C1-4 alkyl groups; or R9 and R10 together with the N atom to which they are attached, constitute a heterocyclic radical, saturated or unsaturated, of 5 to 11 atoms, bridged or not, which comprises or not a spherical C and that contains, or not, a second heteroatom chosen from O or N, and said radical is unsubstituted or substituted by a hydroxyl or phenyl group or once or several times by a C1-4 alkyl and / or C1-4 alkoxy group; R11 represents an H atom, a C1-4 alkyl or C3-7 cycloalkyl group; n represents 0, 1 or 2; Alk represents a C1-4 alkyl group; in a state of base or of addition salts with an acid, as well as in a state of hydrate or solvate. |
| priorityDate | 2003-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.