http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-045819-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 |
| filingDate | 2004-09-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-045819-A1 |
| titleOfInvention | DERIVATIVES OF BENZIMIDAZOL COMPOSITIONS THAT CONTAIN THEM, PREPARATION OF THE SAME AND USES OF THE SAME |
| abstract | This refers to compounds that are useful in therapy, in particular for the treatment of pain. Claim 1: A compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, R5R6N-C1-6 alkyl, R5O- C1-6 alkyl, R5C (= O) N (-R6) -C1-6 alkyl, R5R6NS (= O) 2-C1-6 alkyl, R5CS (= O) 2N (-R6) -C1-6 alkyl, R5R6NC (= O) N (-R7) -C1-6 alkyl, R5R6NS (= O) 2N (R7) -C1-6 alkyl, aryl (C6-10) - alkyl (C1-6), aryl (C6-10) -C (= O) -C1-6 alkyl, (C3-10) cycloalkyl-(C1-6) alkyl, (C4-8) cycloalkenyl-(C1-6) alkyl, heterocyclyl (C3-6) -alkyl (C1 -6), heterocyclyl (C3-6) -C (= O) -C1-6 alkyl, C1-10 hydrocarbylamino, R5R6N-, R5O-, R5C (= O) N (-R6) -, R5R6NS (= O) 2-, R5CS (= O) 2N (-R6) -, R5R6NC (= O) N (-R7) -, R5R6NS (= O) 2N (R7) -, C6-10 aryl, aryl (C6-10) - C (= O) -, C3-10 cycloalkyl, C4-8 cycloalkenyl, C3-6 heterocyclyl and (C3-6) heterocyclyl -C (= O) -; wherein said C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, (C6-10) aryl (C1-6) alkyl, (C6-10) aryl -C (= O) -C 1-6 alkyl, cycloalkyl (C3-10) -C1-6 alkyl, cycloalkenyl (C4-8) -alkyl (C1-6), heterocyclyl (C3-6) -alkyl (C1-6), heterocyclyl (C3-6) -C ( = O) -C1-6 alkyl, hydrocarbonylamino (C1-10), aryl C6-10, aryl (C6-10) -C (= O) -, C3-10 cycloalkyl, C4-8 cycloalkenyl, C3-6 heterocyclyl heterocyclyl (C3-6) -C (= O) - used in the definition of R1 are optionally substituted with one or more groups selected from halogen, cyano, nitro, methoxy, ethoxy, methyl, ethyl, hydroxy and -NR5R6; R2 is selected from C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, (C3-10) cycloalkyl (C1-6) alkyl, (C4-8) cycloalkenyl (C1-6 alkyl) ), (C3-6) heterocycloalkyl (C1-6) alkyl, C4-8 cycloalkenyl, C3-5 heteroaryl, C6-10 aryl and C3-6 heterocycloalkyl, wherein said C1-10 alkyl, C2-10 alkenyl , C2-10 alkynyl, C3-8 cycloalkyl, (C3-8) cycloalkyl (C1-6) alkyl, (C4-8) cycloalkenyl-(C1-6) alkyl, (C3-6) heterocycloalkyl (C1-) alkyl 6), C4-8 cycloalkenyl, C3-5 heteroaryl, C6-10 aryl or C3-6 heterocycloalkyl, used in the definition of R2 are optionally substituted with one or more groups selected from halogen, cyano, nitro, methoxy, ethoxy, methyl , ethyl, hydroxy and -NR5R6; where R5, R6 and R7 are independently selected from -H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and a divalent C1-6 group which together with another divalent R5, R6 or R7 forms a portion of a ring ; R3 is selected from -H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, (C3-10) cycloalkyl (C1-6) alkyl, (C4-8) cycloalkenyl ( C1-6), C3-6 heterocycloalkyl, or a group of formulas (2), optionally substituted with one or more groups selected from C1-6 alkyl, halogen, amino and C1-6 alkoxy; each of R8 and R9 is independently selected from -H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, (C3-10) cycloalkyl (C1-6) alkyl, C3- heterocyclyl 6, C6-10 aryl, (C3-6) heterocyclyl (C1-6) alkyl, (C6-10) aryl (C1-6) alkyl and a divalent C1-6 group which together with another divalent group selected from R8 and R9 forms a portion of a ring, wherein said C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, (C3-10) cycloalkyl (C1-6) alkyl, C3-6 heterocyclyl, C6-10 aryl, (C3-6) heterocyclyl (C1-6) alkyl, (C6-10) aryl (C1-6) alkyl or a divalent C1-6 group is optionally substituted with one or more groups selected from halogen , cyano, nitro, methoxy, ethoxy, methyl, ethyl, hydroxy and -NR5R6; and R4 is selected from -H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 cycloalkyl, (C3-10) cycloalkyl (C1-6) alkyl and (C4-8) cycloalkenyl (C1-6). |
| priorityDate | 2003-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.