http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-045384-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dac022280ec96f54c694eb427655932 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C381-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C381-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2004-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-045384-A1 |
| titleOfInvention | BENZOILGUANIDINAS REPLACED WITH PENTAFLUOROSULFANILFENILO, PROCEDURES FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND AND USE |
| abstract | This refers to benzoylguanidines substituted with pentafluorosulfanylphenyl, these compounds are suitable as antiarrhythmic drugs with a cardioprotective component for the prophylaxis of infarction and the treatment of infarction and for the treatment of angina pectoris. They also prevent preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of cardiac arrhythmias induced by ischemia. Claim 1: A benzoylguanidine substituted with pentafluorosulfanylphenyl of formula (1) or (2) in which the meanings are R1 and R1 ', independently of one another, H, C1-4 alkyl, C1-4 alkoxy, F, Cl, Br , I, -CN, NR5R6, -Oa- (CH2) b- (CF2) c-CF3 or - (SOd) e- (CH2) f- (CF2) g-CF3; R5 and R6, independently of each other, H, C1-4 alkyl, or -CH2-CF3; d 0, 1 or 2; a, b, c, e, f and g, independently of one another, 0, or 1; R2 and R2´ independently of each other, H, F, Cl, Br, I, -CN, SO2CH3, C1-4 alkoxy, nr5r6, -Oa- (ch2) b- (CF2) b- (CF2) c-CF3 , - (SOh) k- (CH2) l- (CF2) m-CF3, C1-6 alkyl, C3-8 cycloalkyl, in which 1, 2, 3, or 4 atoms of H may be substituted by atoms of f , - (CH2) n-phenyl which is unsubstituted or substituted with 1, 2, or 3 radicals selected from the group consisting of F, Cl, Br, I, -Oo- (CH2) p-CF3, C1-4 alkoxy , C1-4 alkyl and -SO2CH3, or - (CH2) q-heteroaryl which is unsubstituted or substituted with 1, 2, or 3 radicals selected from the group consisting of F, Cl, Br, I, -Or- (CH2 ) s-CF3, C1-4 alkoxy, C1-4 alkyl, and -SO2CH3; R5 and R6 independently of one another, H, C1-4 alkyl or -CH2-CF3; a, b and c, independently of one another, 0 or 1; h 0, 1 or 2; k 0 or 1; l 0, 12, 2, 3 or 4; m and o, independently of one another, 0 or 1; p 0, 1, 2 or 3; n 0, 1, 2, 3, or 4; r 0 or 1; s 0, 1, 2 or 3; 0, 1, 2, 3 or 4; R3 and R3 ', independently of each other, H, F, Cl, Br, i, -CN, -SO2CH3, C1-6 alkyl, or -Ot- (CH2) or-CF3; t 0 or 1; or 0, 1, 2 or 3; R4 H, F, Cl, Br, I, -CN, -SO2CH3, NR5R6, - (SOv) w- (CH2) x- (CF2) v-CF3, -Oz- (CH2) aa- (CF2) bb- CF3, C3-8 alkyl, in which 1, 2, 3 or 4 H atoms may be substituted by F atoms; R5 and R6, independently of each other, H, C1-4 alkyl or -CH2-CF3; v 0 1, or 2; x 0, 1, 2, 3 or 4; w, y, z, aa and bb, independently of one another, 0 or 1; or R4 - (CH2) cc-phenyl which is unsubstituted or substituted with 1, 2, or 3 radicals selected from the group consisting of F, Cl, Br, I, -Odd- (CH2) ee-CF3, C1- alkoxy 4, C1-4 alkyl and -SO2CH3; dd 0 or 1; ee 0, 1, 2 or 3; cc 0, 1, 2, 3 or 4; or R4 - (CH2) ff-heteroaryl which is unsubstituted or substituted with 1, 2 or 3 radicals selected from the group consisting of F, Cl, Br, I, -Ogg- (CH2) hh-CF3, C1-4 alkoxy , C1-4 alkyl and -SO2CH3; gg 0 or 1; hh 0, 1, 2 or 3; ff 0, 1, 2, 3 or 4; X a direct junction, O, NR7, S (O) kk; R7 h, C1-4 alkyl, - (CH2) mm-CF3 or -SO2CH3; kk 0, 1 or 2; mm 0, 1, 2 or 3; where -Oa- (CH2) b- (CF2) c-CF3 in the definitions of R1 and R1´ and R2 and R2´ can be independently selected from each other, where NR5R6 in the definitions of 1 and R1´, R2 and R2 ´and R4 can be independently selected from each other, and their pharmaceutically acceptable salts. |
| priorityDate | 2003-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.