http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-044943-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06026 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 |
| filingDate | 2004-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a0c70dd32466b232c55b736c15671c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5c79ee99565f9ce4e0f3c7c073f9c14 |
| publicationDate | 2005-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-044943-A1 |
| titleOfInvention | PROCEDURE FOR SYNTHESIS OF PERINDOPRIL AND PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME |
| abstract | Procedure for the synthesis of perindopril of formula (1) and pharmaceutically acceptable salts thereof. Claim 1: Method for the synthesis of the compounds of formula (1) and pharmaceutically acceptable salts thereof, characterized in that the compound of the formula (2) is reacted with a compound of formula (3) in which X1 and X2, which may be identical or different, each represents an output group to obtain the compound of formula (4) which is reacted with a compound of formula (5) in which R represents an atom e H or a linear or branched C1-6 alkyl or benzyl group, or an addition salt thereof with a mineral or organic acid, to obtain, after isolation, a compound of formula (6) in which R is such as to be defined above, that it is hydrogenated in the presence of a catalyst such as, for example, palladium, platinum, rhodium or nickel, under a pressure of H ranging from 1 to 30 bar, to obtain after deprotection of the acid function, when necessary, perin dopril of formula (1), which is converted, if desired, into a pharmaceutically acceptable salt such as tert-butylamine salt. |
| priorityDate | 2003-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.