http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-044938-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50eb752940fa4aa36756a6bc9f6f3504 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-71 |
| filingDate | 2004-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-044938-A1 |
| titleOfInvention | VEGF TRAPS AND THERAPEUTIC USES OF THE SAME |
| abstract | Nucleic acid molecules and multimeric proteins capable of binding with vascular endothelial growth factor (VEGF). VEGF mini-traps are described that are therapeutically useful for the treatment of disorders and diseases associated with VEGF, and are specifically designed for local administration to specific organs, tissues and / or cells. Claim 1: An isolated nucleic acid molecule encoding a fusion polypeptide, consisting of components (R12) xo (R13) and, and a multimerizing component (MC) that is capable of interacting with another MC to form a multimeric structure , where X> equal 1, Y> equal 1, R1 is the Flt-1 domain 2 of the Ig of the vascular endothelial cell growth factor receptor component (VEGF)., and R2 is the Flk-3 domain 1 of the Ig of the VEGF receptor component, R3 is domain 3 of the Flt-4 Ig. Claim 2: The isolated nucleic acid molecule of claim 1, wherein the multimerizing component (MC) is selected from the group consisting of (i), an MC comprising a dissociable region (region C), (ii) a Truncated MC, (iii) an amino acid sequence between 1 and about 200 amino acids in length that is at least one cysteine residue, (iv) a leucine zipper, (v) a helix curl motif, (vi ) a spiral-spiral motif, and (vii) an immunoglobulin domain. Claim 5: A replicable expression vector suitable in a transformed host cell, comprising the nucleic acid molecule of claim 1 or 2. Claim 11: The method of claim 10, wherein the disease or disorder is a disease or eye disorder |
| priorityDate | 2003-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.