http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-044824-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-12 |
| filingDate | 2004-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-044824-A1 |
| titleOfInvention | AGELISTS OF THE RECEIVER OF MELANOCORTINA 4 (MC4), PHARMACEUTICAL COMPOSITION AND ITS USES |
| abstract | This refers to MC4 receptor agonists and, as such, are useful in the treatment of disorders that respond to the activation of this receptor, such as obesity, diabetes mellitus and male and / or female sexual dysfunction. Claim 1: A compound of the formula (1) and its pharmaceutically acceptable salts, wherein W is Glu, Gln, Asp, Asn, Ala, Gly, Thr, Ser, Pro, Met, Ile, Val, Arg, His, Tyr, Trp, Phe, Lys, Leu, Cya or is absent; R1 is -H, -C (O) CH3, -C (O) (CH2) 1-4CH3, -C (O) (CH2) 1-4NHC (NH) NH2, Tyr-betaArg-, Ac-Tyr-beta -hArg-, gluconoyl-Tyr-Arg-, Ac-diaminobutyryl-, Ac-diaminopropionyl-, N-propionyl-, N-butyryl-, N-valeryl-, N-methyl-Tyr-Arg-, N-glutaryl-Tyr -Arg-, N-succinyl-Tyr-Arg-, R6-SO2-NHC (O) CH2CH2C (O) -, R6-SO2NHC (O) CH2CH2C (O) Arg-, R6-SO2NHCH2CH2CH2C (O) -, (cycloalkyl C3-7) carbonyl, phenylsulfonyl, bicyclic arylsulfonyl C8-14, phenyl (CH2) qC (O) -, (bicyclic aryl C8-14) (CH2) qC (O) -, as shown in the compounds of formula (2 ) in which R2 is -H, -NH2, -NHC (O) CH3, -NHC (O) (CH2) 1-4CH3, -NH-TyrC (O) CH3, R6SO2NH-, Ac-Cya-NH-, Tyr-NH-, HO- (C6-H5) -CH2CH2C (O) NH-, or CH3- (C6H5) -C (O) CH2CH2C (O) NH-; R3 is linear or branched C1-4 alkyl, NH2-CH2- (CH2) q-, HO-CH2- (CH3) 2CHNH (CH2) 4-, R6 (CH2) q-, R6SO2NH-, Ser, Ile, as sample in the remains of formulas (3), q is 0, 1, 2 or 3; R6 is a phenyl or a C8-14 bicyclic aryl; m is 1 or 2; n is 1, 2, 3 or 4; R9 is (CH2) p or (CH3) 2C-; p is 1 or 2; R10 is NH- or is absent; R7 is a 5 or 6 membered heteroaryl or a 5 or 6 membered heteroaryl optionally substituted with R4; R4 is H, linear or branched C1-4 alkyl, phenyl, benzyl or (C6H5) -CH2-O-CH2-; R8 is phenyl, a phenyl ring optionally substituted with X or cyclohexyl; X is H, Cl, F, Br, methyl or methoxy; R11 is -C (O) or -CH2; R5 is -NH2, -OH, glycine, NH2-Pro-Ser-, NH2-Pro-Lys-, HO-Ser-, HO-Pro-Ser-, HO-Lys-, alcohol of -Ser, alcohol of -Ser -Pro, alcohol from -Lys-Pro, HOCH2CH2-O-CH2CH2NH-, NH2-Phe-Arg-, NH2-Glu-, NH2CH2RCH2NH-, RNH-, or RO- where R is a linear or branched C1-4 alkyl; and L is -S-S or -S-CH2-S-. |
| priorityDate | 2003-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.