http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-044283-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5dfc0b033ac4c841466d97a5f28ea32b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 2004-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-044283-A1 |
| titleOfInvention | PROCEDURE TO PREPARE ESPIROLACTONE COMPOUNDS |
| abstract | Claim 1: A process for preparing a compound of the formula (1) or a salt thereof, wherein: T, U, V and W are each independently selected from the group consisting of: nitrogen; and metino; in which the methine group is not substituted or is optionally substituted with a substituent that is selected from the group consisting of: halogen; lower alkyl; hydroxy; and lower alkoxy and in which at least two of T, U, V and W are methine; comprising the steps of: a) forming a spirolactone acid halide of the formula (2), wherein X is chlorine or bromine and T, U, V and W are as defined above, treating the compound of the formula (1) with a halogenating agent in a solvent; b) forming a spirolactone ester of the formula (3), wherein R3 is selected from the group consisting of tert-butyl, methylcyclohexyl, methylcyclopentyl and neopentyl and T, U, V and W are as defined above, treating the spirolactone acid halide of the formula (2) with a base and an alcohol in a solvent; c) forming a spirolactone acid of the formula (1), in which T, U, V and W are defined as above, by hydrolyzing the spirolactone ester of the formula (3) with an aqueous acid; and d) isolate the resulting product. |
| priorityDate | 2003-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.