http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-043690-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate | 2004-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-043690-A1 |
| titleOfInvention | DERIVATIVES OF AVERMECTINES AND MONOSACARIDS OF AVERMECTINES, SUBSTITUTES IN THE POSITION 4 "- OR 4'-, WITH PESTICIDED PROPERTIES |
| abstract | Claim 1: A compound of the formula (1) in which n is 0 or 1; X-Y is -CH = CH- or -CH2-CH2-; R1 is C1-12 alkyl, C3-8 cycloalkyl or C2-12 alkenyl; and R2 is R3-Z-, R3-O-Z-, R4 or -Z-N (R6) (R7); Z is -C (= O) -, - C (= S) - or -SO2-; Q is O or -N-R5; R3 and R4 are H, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-12 cycloalkyl, C5-12 cycloalkenyl, aryl or heterocyclyl, wherein alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl radicals and heterocyclyl can be, (depending on the possibilities of substitution), unsubstituted or mono to substituted pentas; Either R5 is H, C1-8 alkyl, hydroxy-C1-8 alkyl, C3-8 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl, phenyl, benzyl, -C (= O) -R9, or -CH2- C (= O) -R9; or, when Q is NR5 and R2 is R4, R4 and R5 together are an alkylene bridge of three to seven members, which is unsubstituted or mono- to trisubstituted; or a three to seven membered alkylene or alkenylene bridge that is unsubstituted or mono- to trisubstituted, and in which one or two of the methylene groups of the bridge are replaced with O, NR8, S, S (= O) or SO2 ; R6 and R7 are, independently of each other, H, unsubstituted C1-12 alkyl or mono to pentasubstituted, C2-12 alkenyl or mono to pentasubstituted, C2-12 alkynyl unsubstituted or mono to pentasubstituted, C3-12 cycloalkyl not substituted or mono to pentasubstituted, C5-12 cycloalkenyl unsubstituted or mono to pentasubstituted, aryl unsubstituted or mono to pentasubstituted, or unsubstituted heterocyclyl or mono to pentasubstituted; or R6 and R7 together are an alkylene bridge of three to seven members, which is unsubstituted or mono- to trisubstituted; or a three to seven membered alkylene or alkenylene bridge that is unsubstituted or mono- to trisubstituted, and in which one or two of the methylene groups of the bridge are replaced with O, NR8, S, S (= O) or SO2 ; R8 is H, C1-8 alkyl, hydroxy-C1-8 alkyl, C3-8 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl, phenyl, benzyl, -C (= O) R9 or -CH2-C (= O ) -R9; in which the substituents of the alkyl, alkenyl, alkynyl, alkylene, cycloalkyl, cycloalkenyl, aryl and heterocyclyl radicals mentioned in R2, R3, R4, R5, R6, R7 and R8 are selected from the group consisting of OH, = O, SH , = S, -N3, halogen, halo-C1-C2alkyl, CN, SCN, NO2, trialkylsilyl, C1-12 alkyl, -C1-12 haloalkyl, C2-8 alkenyl, C2-6 haloalkenyl, C2-8 alkynyl, cycloalkyl C3-8 which is unsubstituted or substituted with one to three methyl, norbornylenyl, C3-8 halocycloalkyl, C1-12 alkoxy, C1-12 alkoxy alkoxy, C1-12 haloalkoxy, C3-8 cycloalkoxy, C1-12 alkylthio groups, C3-8 cycloalkylthio, C1-12 haloalkylthio, C1-12 alkylsulfinyl, C3-8 cycloalkylsulfinyl, C1-12 haloalkylsulfinyl, C1-12 halocycloalkylsulfinyl, C1-12 alkylsulfonyl, C1-12 cycloalkylsulfonyl, C1-12 haloalkylsulfonyl C3-8alkyl , -N (R12) 2 where the two R12 are independent of each other, -C (= O) R9, -OC (= O) R10, -NHC (= O) R9, -SC (= S) R10, -P (= O) (Oalkyl) 2, -S (= O )) 2R13, -NH-S (= O) 2R13, -OC (= O) -alkyl-S (= O) 2R13, aryl, benzyl, heterocyclyl, aryloxy, benzyloxy, heterocyclyl-oxy, arylthio, benzylthio and heterocyclyl; wherein the aryl, heterocyclyl, aryloxy, benzyloxy, heterocyclyloxy, arylthio, benzylthio or heterocyclyl radical radicals are unsubstituted or, depending on the possibilities of substitution in the ring, mono-to penta substituted with substituents selected from the group consisting of OH, halogen, CN , NO2, C1-12 alkyl, C3-8 cycloalkyl, C1-12 haloalkyl, C1-12 alkoxy, C1-12 haloalkoxy, C1-12 alkylthio, C1-12 haloalkyl, C1-6 alkoxy-C1-6 alkyl, dimethylamino- C1-6 alkoxy, C2-8 alkenyl, C2-8 alkynyl, phenyl, phenoxy, phenyl-C1-6 alkyl, methylenedioxy, -C (= O) R9, -OC (= O) -R10, -NH-C ( = O) R10, -N (R12) 2 wherein the two R12 are independent of each other, C1-6-sulfinyl alkyl, C3-8 cycloalkylsulfinyl, C1-6 haloalkylsulfinyl, C3-8 halocycloalkylsulfinyl, C1-6 alkylsulfonyl, cycloalkylsulfonyl C3-8, C1-6 haloalkylsulfonyl and C3-8 halocycloalkyl sulfonyl; R9 is H, OH, SH, -N (R12) 2 where the two R12 are independent of each other, C1-24 alkyl, C2-12 alkenyl, C1-8 hydroxyalkyl, C1-12 haloalkyl, C1-12 alkoxy, C 1-12 haloalkoxy, C 1-6 alkoxy-C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkoxy, C 1-6 alkoxy-C 1-6 alkoxy-C 1-6 alkyl, C 1-12 alkylthio, C 2-8 alkenyloxy, C3-8 alkynyloxy, -NH-C1-6-C alkyl (= O) -R11, -N (C1-6 alkyl) -C1-6-C alkyl (= O) -R11, -O-C1-6 alkyl -C (= O) R11, -C 1-6 alkyl-S (= O) 2R13, aryl, benzyl, heterocyclyl, aryloxy, benzyloxy, heterocyclyloxy; or aryl, benzyl, heterocyclyl, aryloxy, benzyloxy or heterocyclyloxy, which are unsubstituted or mono-trisubstituted in the ring independently of one another with halogen, nitro, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl or haloalkoxy C1-6; R10 is H, C1-24 alkyl, C1-12 haloalkyl, C1-12 hydroxyalkyl, C2-8 alkenyl, C2-8 alkynyl, C1-6 alkoxy-C1-6 alkyl, -N (R12) 2 wherein the two R12 are independent of each other, -C1-6-C alkyl (= O) R12, -C1-6-S alkyl (= O) 2R13, aryl, benzyl, heterocyclyl; or aryl, benzyl or heterocyclyl which, depending on the possibilities of substitution in the ring, are mono-trisubstituted with substituents selected from the group consisting of OH, halogen, CN, NO2, C1-12 alkyl, C1-12 haloalkyl, C1 alkoxy -12, C1-12 haloalkoxy, C1-12 alkylthio and C1-12 haloalkyl; R11 is H, OH, C1-24 alkyl which is optionally substituted with OH, or -S (= O) 2-C1-6 alkyl, C2-12 alkenyl, C2-12 alkynyl, C1-12 alkoxy, C1-6 alkoxy -C1-6 alkyl, C1-6 alkoxy-C1-6 alkoxy, C2-8 alkenyloxy, aryl, aryloxy, benzyloxy, heterocyclyl, heterocyclyloxy or -N (R12) 2, wherein the two R12 are independent of each other; R12 is H, C1-6 alkyl, which is optionally substituted with one to five substituents selected from the group consisting of OH, = O, halogen, C1-6 alkoxy, hydroxy and cyano; C1-8 cycloalkyl, aryl, benzyl, heteroaryl; or aryl, benzyl or heteroaryl, which depending on the possibilities of substitution in the ring, are mono- to trisubstituted with substituents selected from the group consisting of OH, halogen, CN, NO2, alkyl, haloalkyl, alkoxy, C1-12 haloalkoxy, alkylthio C1-12 and C1-12 haloalkylthio; or the two R12 together are a three to seven membered alkenylene or alkylene bridge, which is unsubstituted or mono-trisubstituted, and in which one of the methylene groups of the bridge is replaced with O, NR8, S, S (= O) or SO2; R13 is H, C1-6 alkyl which is optionally substituted with one five substituents selected from the group consisting of hydroxy, halogen, = O, C1-6 alkoxy, hydroxy and cyano; aryl, benzyl, heteroaryl; or aryl, benzyl or heteroaryl, which depending on the possibilities of substitution in the ring, are mono- to trisubstituted with substituents selected from the group consisting of OH, = O, halogen, CN, NO2, C1-12 alkyl, C1-12 haloalkyl , C1-12 alkoxy, C1-12 haloalkoxy, C1-12 alkylthio and C1-12 C1-6 haloalkyl; or, if applicable, an E / Z isomer, a mixture of E / Z isomers and / or a tautomer thereof, in each case in free form or in salt form. |
| priorityDate | 2003-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 27.