http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-043684-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd47318319f20f7f99d9fef1fd3e511b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-12 |
| filingDate | 2003-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_297546d6a390ebac03283b71df2296df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09d869054cdf321aed90f495ff7f1df1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c30ff434f496094c24506c3347a4df84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d33424e1311bb56f988b6943bafbab9a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f906390af3f1f492a2b072ac8d6c67c8 |
| publicationDate | 2005-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-043684-A1 |
| titleOfInvention | CCR8 INHIBITORS, COMPOUND, PHARMACEUTICAL COMPOSITION AND USES |
| abstract | A CCR8 inhibitor that is represented by structural formula (1). Pharmaceutical compositions comprising a pharmaceutically acceptable diluent or carrier and a CCR8 inhibitor represented by structural formula (1). Claim 1: A compound represented by structural formula (1) or a pharmaceutically acceptable salt thereof, wherein: X1 is a covalent bond, C = O or CRaRb; X is a covalent bond, O, or NR5; C = Z is C = O, CH2, C = NH, C = S or is absent, in the well understood that when X1 is a covalent bond then C = Z is not CH2, in the well understood that when C = Z is absent then X is a covalent bond, and in the understanding that when X is NR5 and C = Z is C = O then R4 is not a substituted aliphatic or aliphatic group; Ra and Rb are independently H or a C1-C3 alkyl; R1 is: i) a substituted or unsubstituted aromatic group; ii) a substituted or unsubstituted non-aromatic ring; or iii) when X is NR5, then NR5- (CH2) mR1, taken together, is optionally a substituted or unsubstituted non-aromatic heterocyclic group; R2 is -H or a C1-C3 alkyl group; R3 is -H; and R4 is: i) a substituted or unsubstituted aliphatic group; ii) a substituted or unsubstituted aromatic group; iii) a substituted or unsubstituted non-aromatic ring or a substituted or unsubstituted non-aromatic bridged bicyclic group; or iv) R3 and R4 taken together, with the nitrogen atom to which they are attached are a non-aromatic heterocyclic group containing substituted or unsubstituted nitrogen; R5 is -H, or a C1-C3 alkyl group; ring B is a phenyl group or a five or six membered carbocyclic non-aromatic ring fused with ring A; rings A and B are optionally substituted with alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxy, halogen, cyano or nitro; m is 0, 1, 2 or 3; n is 1 or 2; each substitutable carbon atom of the aromatic group represented by R1 is optionally substituted with a group represented by R10, where R10 is halogen, -Rs, -OH, -ORs, -O (haloalkyl), -SH, -SRs, 1,2 -methylene-dioxy, 1,2-ethylenedioxy, phenyl (Ph), substituted Ph, -O (Ph), -O (Ph) substituted, -CH2 (Ph), -CH2 (Ph) substituted, -CH2CH2 (Ph) , -CH2CH2 (Ph) substituted, -NO2, -CN, -N (R ') 2, -NR'CO2Rs, -NR'C (O) Rs, -NR'NR'C (O) Rs, -N ( R ') C (O) N (R') 2, -NR'NR'C (O) N (R ') 2, -NR'NR'CO2Rs, -C (O) C (O) Rs, -C (O) CH2C (O) Rs, -CO2Rs, -C (O) Rs, -C (O) N (R) -C (O) Rs, -C (O) N (Rs) 2, -OC (O ) Rs, -OC (O) N (Rs) 2, -S (O) 2Rs, -SO2N (R ') 2, -S (O) Rs, -NR'SO2N (R') 2, -NR'SO2Rs , -C (= S) N (R ') 2, - (CH2) and N (R') 2, -C (= NH) -N (R ') 2, haloalkyl, -V-Rs, -V-OH , -V-ORs, -V-SH, -V-SRs, -V-NO2, -V-CN, -VN (R ') 2, -V-NR'CO2Rs, -V-NR'C (O) Rs, -V-NR'NR'C (O) Rs, -VN (R ') C (O) N (R') 2, -V-NR'NR'C (O) N (R ') 2, -V-NR'NR'CO2Rs, -VC (O) C (O) Rs, -VC (O) CH2C (O) Rs, -VC (O) 2Rs, -VC (O) Rs, -VC (O) N (Rs) 2, -V-OC (O) Rs, -V-OC (O) N (Rs) 2, -VS (O) 2Rs, -V-SO2N (R ') 2, -VS (O) Rs, -V-NR 'SO2N (R') 2, -V-NR'SO2Rs, -VC (= S) N (R ') 2, -V- (CH2) and N (R') 2, or -VC (= NH) -N (R ') 2, and each group represented by R10 is independently selected; each substitutable carbon atom of the aromatic group represented by R4 is optionally substituted with a group represented by R11, where R11 is halogen, -Rs, -OH, -ORs, -O (haloalkyl), -SH, -SRs, 1,2 -methylene-dioxy, 1,2-ethylenedioxy, phenyl (Ph), substituted Ph, -O (Ph), -O (Ph) substituted, -CH2 (Ph), -CH2 (Ph) substituted, -CH2CH2 (Ph) , -CH2CH2 (Ph) substituted, -NO2, -CN, -N (R ') 2, -NR'CO2Rs, -NR'C (O) Rs, -NR'NR'C (O) Rs, -N ( R ') C (O) N (R') 2, -NR'NR'C (O) N (R ') 2, -NR'NR'CO2Rs, -C (O) C (O) Rs, -C (O) CH2C (O) Rs, -C (O) Rs, -C (O) N (Rs) 2, -OC (O) Rs, -OC (O) N (Rs) 2, -S (O) 2Rs, -SO2N (R ') 2, -S (O) Rs, -NR'SO2N (R') 2, -NR'SO2Rs, -C (= S) N (R ') 2, - (CH2) and N (R ') 2, -C (= NH) -N (R') 2, haloalkyl, -V-Rs, -V-OH, -V-ORs, -V-SH, -V-SRs, -V- NO2, -V-CN, -VN (R ') 2, -V-NR'CO2Rs, -V-NR'C (O) Rs, -V-NR'NR'C (O) Rs, -VN (R ') C (O) N (R') 2, -V-NR'NR'C (O) N (R ') 2, -V-NR'NR'CO2Rs, -VC (O) C (O) Rs , -VC (O) CH2C (O) Rs, -VC (O) 2Rs, -VC (O) Rs, -VC (O) N (Rs) 2, -V-OC (O) Rs, -V-OC (O) N (Rs) 2, -VS (O) 2Rs, -V-SO2N (R ') 2, -VS (O) Rs, -V-NR'SO2N (R') 2, -V-NR ' SO2Rs, -VC (= S) N (R ') 2, -V- (CH2) and N (R') 2, -VC (= NH) -N (R ') 2, = NNHR *, = NN (R *) 2, = NNHC (O) R *, = NNHCO2 (alkyl), = NNHSO2 (alkyl), or = NR *, and each group represented by R11 is independently selected; each substitutable carbon atom of the aromatic group represented by R4 is optionally substituted with a group represented by R12, where R12 is halogen, -Rs, -OH, -ORs, -O (haloalkyl), -SH, -SRs, 1,2 -methylene-dioxy, 1,2-ethylenedioxy, phenyl (Ph), substituted Ph, -O (Ph), -O (Ph) substituted, -CH2 (Ph), -CH2 (Ph) substituted, -CH2CH2 (Ph) , -CH2CH2 (Ph) substituted, -CN, -NR'CO2Rs, -NR'NR'C (O) Rs, -N (R ') C (O) N (R') 2, -NR'NR'C (O) N (R ') 2, -NR'NR'CO2Rs, -C (O) C (O) Rs, -C (O) CH2C (O) Rs, -CO2Rs, -C (O) Rs, - OC (O) Rs, -OC (O) N (Rs) 2, -S (O) 2Rs, -SO2N (R ') 2, -S (O) Rs, -NR'SO2N (R') 2, - NR'SO2Rs, -C (= S) N (R ') 2, - (CH2) and N (R') 2, -C (= NH) -N (R ') 2, haloalkyl, -V-Rs, - V-OH, -V-ORs, -V-SH, -V-SRs, -V-CN, -V-NR'CO2Rs, -V-NR'C (O) Rs, -V-NR'NR'C (O) Rs, -VN (R ') C (O) N (R') 2, -V-NR'NR'C (O) N (R ') 2, -V-NR'NR'CO2Rs, - VC (O) C (O) Rs, -VC (O) CH2C (O) Rs, -VC (O) 2Rs, -VC (O) Rs, -V-OC (O) Rs, -V-OC (O ) N (Rs) 2, -VS (O) 2Rs, -V-SO2N (R ') 2, -V-NR'SO2Rs, -VC (= S) N (R') 2, -V- (CH2) yN (R ') 2, or -VC (= NH) -N (R') 2, and each group represented by R12 is sele independently operated; each substitutable carbon atom: i) of the non-aromatic ring represented by R1 or R4, ii) of the non-aromatic heterocyclic group formed from NR5 (CH2) mR1; iii) of the non-aromatic nitrogen-containing heterocyclic group formed from NR3R4; iv) of the non-aromatic bridged bicyclic group represented by R4 is optionally and independently substituted with -Rs, -OH, -ORs, -O (haloalkyl), -SH, -SRs, 1,2-methylene-dioxy, 1,2- ethylenedioxy, phenyl (Ph), substituted Ph, -O (Ph), -O (Ph) substituted, -CH2 (Ph), -CH2 (Ph) substituted, -CH2CH2 (Ph), -CH2CH2 (Ph) substituted, - NO2, -CN, -N (R ') 2, -C (O) N (Rs) 2, -NR'C (O) Rs, -NR'CO2Rs, -NR'NR'C (O) Rs, - N (R ') C (O) N (R') 2, -NR'NR'C (O) N (R ') 2, -NR'NR'CO2Rs, -C (O) C (O) Rs, -C (O) CH2C (O) Rs, -CO2Rs, -C (O) Rs, -OC (O) Rs, -OC (O) N (Rs) 2, -S (O) 2Rs, -SO2N (R ') 2, -S (O) Rs, -NR'SO2N (R') 2, -NR'SO2Rs, -C (= S) N (R ') 2, - (CH2) and N (R') 2, -C (= NH) -N (R ') 2, haloalkyl, -V-Rs, -V-OH, -V-OR', -V-SH, -V-SRs, -V-NO2, -V- CN, -VN (R ') 2, -V-NR'CO2Rs, -V-NR'C (O) Rs, -V-NR'NR'C (O) Rs, -VN (R') C (O ) N (R ') 2, -V-NR'NR'C (O) N (R') 2, -V-NR'NR'CO2Rs, -VC (O) C (O) Rs, -VC (O ) CH2C (O) Rs, -VC (O) 2Rs, -VC (O) Rs, -VC (O) N (Rs) 2, -V-OC (O) Rs, -V-OC (O) N ( Rs) 2, -VS (O) 2Rs, -V-SO2N (R ') 2, -VS (O) Rs, -V-NR'SO2N (R') 2, -V-NR'SO2Rs, -VC ( = S) N (R ') 2, -V- (CH2) and N (R') 2, -VC (= NH) -N (R ') 2, = O, = S, = NNHR *, = NN (R *) 2, = NNHC (O) R *, = NNHCO2 (alkyl), = NNHSO2 (alkyl ), y = NR *; each Rs is independently hydrogen or a substituted or unsubstituted aliphatic group, a substituted or unsubstituted cycloaliphatic group, a substituted or unsubstituted non-aromatic heterocyclic group, or a substituted or unsubstituted aromatic group selected from phenyl, naphthyl, 2-furanyl, 3 -furanyl, N-imidazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, 2-oxadiazolyl, 5-oxadiazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl , 1-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 3-pyridazinyl, 2-thiazolyl, 4-thiazolyl, 5 -thiazolyl, 2-triazolyl, 5-thiazolyl, tetrazolyl, 2-thienyl, 3-thienyl, carbazolyl, benzimidazolyl, benzothienyl, benzofuranyl, indolyl, quinolinyl, benzotriazolyl, benzothiazolyl, benzooxazolyl, benzimidazolyl, isoquinolinyl, isoindolyl, acridinyl, or benzoisazolilo; each R1 is independently Rs, -CO2Rs, -SO2Rs or -C (O) Rs: each R * is independently hydrogen, an unsubstituted aliphatic group or a substituted aliphatic group; V is an alkylene group; each substitutable carbon atom: i) of the non-aromatic, cycloaliphatic, aliphatic heterocyclic group and of the aromatic group represented by Rs; and ii) the aliphatic group represented by R * is optionally and independently substituted with amino, alkylamino, dialkylamino, aminocarbonyl, halogen, alkyl, aminoalkyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminocarbonyloxy, dialkylaminocarbonyloxy, alkoxy, nitro, cyano, carboxy, alkoxycarbonyl, alkylcarbonyl, alkyl hydroxy, haloalkoxy, or haloalkyl; each substitutable nitrogen atom: i) of the non-aromatic ring represented by R1 or R4; ii) of the non-aromatic heterocyclic group formed from NR5 (CH2) mR1; iii) of the non-aromatic nitrogen-containing heterocyclic group formed from NR3R4; iv) of the non-aromatic heterocyclic group represented by R 'and v) of the non-aromatic bridged bicyclic group represented by R4 is optionally and independently substituted with R +, -N (R +) 2, -C (O) R +, -CO2R +, -C ( O) C (O) R +, -C (O) CH2C (O) R +, -SO2R +, -SO2N (R +) 2, -C (= S) N (R +) 2, -C (= NH) -N ( R +) 2, -NR + SO2R +, -C (O) -NHR +, -C (O) -N (R +) 2, -C (O) -CH [N (R +) 2] R + or -C (O) - CH [OR +] R +; each R + is independently hydrogen, a substituted heteroaryl or a non-aromatic, aliphatic, cycloaliphatic heterocyclic group, a phenyl or benzyl group, where each substitutable carbon atom of the non-aromatic, aliphatic, cycloaliphatic heterocyclic ring, phenyl or benzyl group, represented by R + it is optionally substituted with amino, alkylamino, dialkylamino, aminocarbonyl, halogen, alkyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylaminocarbonyloxy, dialkylaminocarbonyloxy, alkoxy, nitro, cyano, carboxy, alkoxycarbonyl, alkylcarbonyl, hydroxy, haloalkoxy, or haloalkyl 2 or N (R) non-aromatic heterocyclic group; and each substitutable nitrogen atom of the non-aromatic heterocyclic group represented by R + is optionally substituted by alkyl, alkoxycarbonyl, alkylcarbonyl, alkylaminocarbonyl or dialkylaminocarbonyl, as long as the compound is other than N- [4 - [[(4-methoxyphenyl) amino] sulfonyl] -1-naphthalenyl] -benzamide, N- [4 - [(2-propenylamino) sulfonyl] -1-naphthalenyl] -benzamide, N- [4- (4-morpholinyl sulfonyl) -1-naphthalenyl] -benzamide or N- [4- (1-pi |
| priorityDate | 2002-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 110.