http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-043594-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4cdb1ef9fe36ae01e3729156a7103103 |
| filingDate | 2004-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42ebc252328992cda5763a957c332a86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5134906220db9cba88ef2fdbded231ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_852d1d6e3c06444a4a45ca074047ef2b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88490070aedc9d6665f4cab855fb0f70 |
| publicationDate | 2005-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-043594-A1 |
| titleOfInvention | A PROCEDURE FOR THE PREPARATION OF CALCIUM SALT OF ACID (E) -7- [4- (4-FLUOROPHENIL) -6-ISOPROPIL-2- [METHYL (METHYL-SULFONYL) AMINO] PIRIMIDIN-5-IL] (3R , 5S) -3,5-DIHYDROXIHEPT-6-ENOICO AND COMPOUND USED IN SUCH PROCEDURE |
| abstract | A process for the preparation of the calcium salt of (E) -7- [4- (4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5-yl] (3R, 5S ) -3,5-dihydroxyhept-6-enoic, comprising: i) the preparation of [4- (4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5-ylmethyl] bromine phosphonium (TPPBr) of formula (1); ii) reaction of TPPBr with tert-butyl acetate 2- (4R, 6S) -6-formyl-2,2-dimethyl-1,3-dioxan-4-yl (BFA) of formula (2) to form acetate of tert-butyl (E) -6- {2. [4-fluorophenyl-6-isopropyl-2-methyl (methylsulfonyl) amino] pyrimidin-5-yl] vinyl} - (4R, 6S) -2,2-dimethyl [1,3] -dioxan-4-yl (BEM) of formula (3); iii) preparation of the methylammonium salt of Rosuvastatin and iv) conversion of the methylammonium salt of Rosuvastatin into the calcium salt of Rosuvastatin. |
| priorityDate | 2003-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.