| abstract |
Claim 1: Compounds of the general formula (1A) 0 (1B) wherein R1 and R1 'are the same or different and are H, lower alkyl, halogen, benzyl, lower alkenyl; or together with the C atom to which they are attached are lower cycloalkyl; (R2) 1,2,3 regardless of its occurrence is H, hydroxy, halogen, lower alkyl, lower alkoxy or trifluoromethyl; R3 is phenyl or benzyl, which are unsubstituted or substituted by one or two substituents chosen from the group consisting of halogen and cyano, or is lower alkyl, two H atoms, - (CH2) 1,2-S-lower alkyl, - (CH2) 1,2-cycloalkyl, - (CH2) 1,2-OH, -CH2OCH2-phenyl, or groups of formulas (3); R4 is lower alkoxy, -mono- or dialkylamino, -N (CH3) (CH2) 1,2-C ::: CH, or is a mono-, di- or tricyclic group, unsubstituted or substituted by a residue of R5 to R10 and said groups may be linked by -N (CH3) (CH2) 0,1,2, to the group -C (O) - of the formula (1B), chosen from the group consisting of the moieties of formulas (4) (R5) 1.2 regardless of its occurrence is H, halogen, lower alkyl or - (CH2) 1,2OH; R6 is H, halogen or lower alkoxy; R7 is H or -CH2OCH3; R8 is H or halogen; R9 is H, lower alkoxy, lower alkyl or amino; (R10) 1,2,3 regardless of its occurrence is H, lower alkyl, lower alkoxy, lower cycloalkyl, halogen, hydroxy, = O, amino, nitro, -CH2CN, -OCH2C6H5, or one of the residue groups of formula (5); the remainder of formula (6) may be the following rings, as shown in the residues of formulas (7) in which X is -CH2, -S (O) 2 or -C (O) -; R11 is H or lower alkyl; R12 is H or halogen; R13 is H, CN, hydroxy, -C (O) NH2 or the groups of moieties of formulas (8); R14 is H, lower alkyl, - (CH2) 2OH or - (CH2) 2CN; and to pharmaceutically acceptable acid addition salts thereof. |