| abstract |
Compound of the formula (1) in which: n is an integer selected from 1, 2 and 3; Y represents O; N-OR9, wherein R9 represents H or a saturated hydrocarbon aliphatic group; CR10R11, wherein R10 and R11, which may be identical or different, represent H or a saturated hydrocarbon aliphatic group; R1 and R2, which may be identical or different, represent H or a saturated aliphatic hydrocarbon chain; or, alternatively, R1 and R2 together form an optionally substituted saturated aliphatic hydrocarbon chain; the radicals R3 and R4, which may be identical or different, take any of the meanings indicated above for R1 and R2, or alternatively, R1 and the group R4 carrying the carbon a of CR1R2 represent nothing and a double bond binds CR1R2 carbon to CR3R4 carbon located at a; or alternatively, one of the radicals R1 and R2 forms with one of the radicals R3 and R4 an optionally substituted saturated or unsaturated aliphatic hydrocarbon chain; one of the radicals R5 and R6 represents W, and the other represents Z which is selected from a saturated or unsaturated aliphatic hydrocarbon radical; an optionally substituted saturated, unsaturated and / or aromatic carbocyclic or heterocyclic radical; an -alk-Cy radical, wherein alk represents an alkylene chain and Cy represents an optionally substituted saturated, unsaturated and / or aromatic heterocyclic or carbocyclic radical; W represents -XL-CO2R7; -X-L-Tet, wherein X and L are as defined below and Tet represents optionally substituted tetrazole; wherein L represents a saturated or unsaturated aliphatic hydrocarbon chain, which is optionally substituted and / or optionally interrupted by optionally substituted arylene; X represents O; NR8, in which R8 represents H; a saturated aliphatic hydrocarbon group; a group -CO-R´ or -SO2-R´, in which R´ takes any of the meanings indicated below for R7 with the exception of H; or R8 represents an optionally substituted aromatic carbocyclic group; or X represents S (O) m, in which m is selected from 0, 1 and 2; R7 represents H; a saturated or unsaturated aliphatic hydrocarbon group; an optionally substituted saturated, unsaturated and / or aromatic carbocyclic group; an optionally substituted saturated, unsaturated and / or aromatic heterocyclic group; and its pharmaceutically acceptable derivatives, salts, solvates and stereoisomers, and also mixtures thereof in all proportions; preparation methods and pharmaceutical compositions, which can be used in the treatment of dyslipidemia, atherosclerosis and diabetes. |