| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4ad61541070e490046c1c231cf4f9d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_449898f4ff389ba06802c9f48c6a132c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-44 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 |
| filingDate |
2003-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29ad32806b60bb1d0b028b36830963ef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c2179d2f0a23abe0179ff7d22149938
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87fc0bcb63bff3ff949669a48090b93c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a693b330c04d0c83df1364fd0c0fe05b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4225dae26f3262402531d11b3ce5e57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ce8e13775a83951f8dbb5bcb98ee61a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_991f7451437726bc2ed45e12e3802599 |
| publicationDate |
2005-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AR-042546-A1 |
| titleOfInvention |
PREPARATION PROCEDURE AND CRYSTALLINE FORMS OF MODAFINIL ENANTIOMERS, PHARMACEUTICAL COMPOSITIONS AND MEDICINES CONTAINING THEM |
| abstract |
A process for preparing crystalline forms of modafinil optical enantiomers, comprising the steps consisting of: i) dissolving one of modafinil optical enantiomers in a solvent other than ethanol; ii) crystallize the modafinil enantiomer; iii) recover the crystalline form of the modafinil enantiomer thus obtained. Pharmaceutical compositions comprising the polymorphic form of one enantiomer or another; use of the polymorphic form of both enantiomers for the manufacture of a medicament for the treatment of hypersomia and central nervous system disorders. Claim 31: Method of preparing optically active modafinil from modafinic acid, characterized in that it comprises the following steps: i) to split the two optical enantiomers of the (- +) modafinic acid and recover at least one of the enantiomers; ii) contacting one of the two enantiomers obtained with a lower alkyl haloformate in the presence of alcohol and an organic base; iii) recover the product obtained; iv) convert the ester obtained to amide; v) recover the product obtained in step iv). |
| priorityDate |
2002-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |