http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-042284-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2003-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-042284-A1 |
| titleOfInvention | PIPERIDINE DERIVATIVES, PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM; AND USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES |
| abstract | Preparation of these piperidine derivatives, pharmaceutical compositions and their use as principles of drugs that inhibit the uptake of serotonin and / or neropinephrine and / or dopamine, useful for the treatment of disorders of the central nervous system or peripheral nervous system. Claim 1: A compound of formula (1), wherein: n is 1, 2 or 3; R1 is C2-10 alkyl, C2-10 alkenyl, C3-8 cycloalkyl, or (C4-10) cycloalkyl, where a CC bond within any cycloalkyl moiety is finally substituted with an OC, SC or C = C bond and where each group is optionally substituted with 1 to 7 halogen substituents and / or with 1 to 3 substituents each independently selected from hydroxy, cyano, C1-4 alkyl, C1-4 alkylthio (optionally substituted with 1 to 3 atoms of halogen) and C1-4 alkoxy (optionally substituted with 1 to 3 halogen atoms); R2 is H, C1-4 alkyl (optionally substituted with 1 to 7 halogen atoms), (C1-4) alkyl -S (O) x- where x is 0, 1 or 2 (optionally substituted with 1 to 7 atoms of halogen), C1-4 alkoxy (optionally substituted with 1 to 7 halogen atoms), cyano, halogen, phenyl (optionally substituted with 1 to 3 substituents each independently selected from halogen, (C1-4) alkyl-alkoxy ( C1-4)), phenoxy (optionally substituted with 1 to 3 substituents each selected from halogen, (C1-4) alkyl and (C1-4) alkoxy) or -CO2 (C1-4 alkyl) or together with R3 it forms an additional benzene ring (optionally substituted with 1 to 3 substituents each selected from halogen, (C1-4) alkyl and (C1-4) alkoxy); R3 is H, alkyl 1-4 (optionally substituted with 1 to 7 halogen atoms), (C1-4) alkyl -S (O) x- where x is 0, 1 or 2 (optionally substituted with 1 to 7 atoms of halogen), C1-4 alkoxy (optionally substituted with 1 to 7 halogen atoms), cyano, halogen, phenyl (optionally substituted with 1 to 3 substituents, each selected from halogen, (C1-4) alkyl and alkoxy ( C1-4)), phenoxy (optionally substituted with 1 to 3 substituents each selected from halogen, (C1-4) alkyl and (C1-4) alkoxy) or -CO2 (C1-4 alkyl) or together with R3 it forms an additional benzene ring (optionally substituted with 1 to 3 substituents each independently selected from halogen, (C1-4) alkyl and (C1-4) alkoxy); R4 is H, alkyl, alkyl 1-4 (optionally substituted with 1 to 7 halogen atoms), (C1-4) alkyl -S (O) x- where x is 0, 1 or 2 (optionally substituted with 1 to 7 halogen atoms), C1-4 alkoxy (optionally substituted with 1 to 7 halogen atoms), cyano, halogen, phenyl (optionally substituted with 1 to 3 substituents, each independently selected from halogen, (C1-4) alkyl and (C1-4) alkoxy), phenoxy (optionally substituted with 1 to 3 substituents each independently selected from halogen, (C1-4) alkyl and (C1-4) alkoxy) or -CO2 (C1-4 alkyl) or together with R3 forms an additional benzene ring (optionally substituted with 1 to 3 substituents each independently selected from halogen, (C1-4) alkyl and (C1-4) alkoxy); R5 is H, C1-4 alkyl (optionally substituted with 1 to 7 halogen atoms), C1-4 alkoxy (optionally substituted with 1 to 7 halogen atoms) or halogen; R6 is H, C1-4 alkyl (optionally substituted with 1 to 7 halogen atoms), C1-4 alkoxy (optionally substituted with 1 to 7 halogen atoms) or halogen; R7 is H or C1-4 alkyl; R8 is H or C1-4 alkyl; R9 is H, halogen, hydroxy, cyano, C1-4 alkyl or C1-4 alkoxy; and r10 is H, halogen, hydroxy, cyano, C1-4 alkyl or C1-4 alkoxy; or a pharmaceutically salt thereof, with the proviso that the compound N-ethyl-benzyl-4-piperidinamine is excluded. Claim 20: A process for producing a compound according to any of the preceding claims, comprising deprotecting a compound of formula (2), wherein R is a protective group of N and R1 to R10 are as defined in the claim 1, optionally followed by the step of forming a pharmaceutically acceptable salt. |
| priorityDate | 2002-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.