http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-042282-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-33 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-33 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 |
| filingDate | 2003-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-042282-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF PHENYLMALONIC ACID DINITRILS |
| abstract | Claim 1: A process for the preparation of a compound of the formula (1), in which: each of the R0, regardless of which (s) another one (s) wants, is halogen, C1-6 alkyl, C2 alkenyl -6, C2-6 alkynyl, C1-6 haloalkyl, cyano-C1-6 alkyl, C2-6 haloalkenyl, cyano-C2-6 alkenyl, C2-6 haloalkynyl, cyano-C2-6 alkynyl, hydroxy, hydroxy (C1-6) alkyl, C1-6 alkoxy, nitro, amino, C1-6 alkylamino, di (C1-6 alkyl) amino, C1-6 alkylcarbonylamino, C1-6 alkylsulfonylamino, C1-6 alkylaminosulfonyl, alkylcarbonyl C1-6, (C1-6) alkylcarbonyl (C1-6) alkyl, (C1-6) alkoxycarbonyl (C1-6) alkyl, (C1-6) alkylcarbonyl (C2-6) alkenyl, C1-6 alkoxycarbonyl , (C 1-6) alkoxycarbonyl (C 2-6) alkenyl, C 1-6 alkylcarbonyl (C 2-6) alkynyl, C 1-6 alkoxycarbonyl (C 2-6) alkynyl, cyano, carboxy, phenyl or a aromatic ring containing 1 or 2 heteroatoms selected in the nitrogen, oxygen and sulfur group, where the two aromatic rings mentioned last term may be substituted with C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, halogen, cyano or with nitro; or R0, together with the adjacent substituents R1, R2 and R3, forms a C3-6 hydrocarbon bridge, saturated or unsaturated, which may be interrupted by 1 or 2 heteroatoms selected from the nitrogen, oxygen and sulfur group, and / or substituted with C1-4 alkyl; R1, R2 and R3, independently of one another, are hydrogen, halogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, haloalkyl 1-6, haloalkyl C2-6, alkoxycarbonyl (C1-6 ) - (C2-6) alkenyl, (C1-6) alkylcarbonyl (C2-6) alkenyl (C2-6) cyano-alkenyl (C2-6), C2-6 haloalkyl, (C1- alkoxycarbonyl) 6) - (C2-6) alkynyl, (C1-6) alkylcarbonyl (C2-6) alkynyl (C2-6) alkynyl, (C2-6) alkynyl, C3-6 halocycloalkyl, hydroxy-alkyl (C1-6), (C1-6) alkoxy-(C1-6) alkyl, (C1-6) alkylthio (C1-6) alkyl, cyano, C1-4 alkylcarbonyl, C1-6 alkoxycarbonyl, hydroxy, C1 alkoxy -10, C3-6 alkenyloxy, C3-6 alkynyloxy, C1-6 haloalkoxy, C3-6 haloalkyloxy, C3-6 alkoxy, (C1-6) alkoxy (C1-6) alkoxy, mercapto, C1-6 alkylthio, haloalkyl C1-6, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, nitro, amino, C1-6 alkylamino, di (C1-6 alkyl) amino or phenoxy, where the phenyl ring may be substituted with C1-3 alkyl, C1- haloalkyl 3, C1-3 alkoxy, C1-3 haloalkoxy, c iano or with nitro; R2 may additionally be phenyl, naphthyl or a 5- or 6-membered aromatic ring that may contain 1 or 2 heteroatoms selected from the nitrogen, oxygen and sulfur group, where the phenyl ring, the naphthyl ring and the 5 or 6-membered aromatic ring may be substituted with halogen, C3-8 cycloalkyl, hydroxy, mercapto, amino, cyano, nitro or with formyl; and / or the phenyl ring, the naphthyl ring and the 5- or 6-membered aromatic ring may be substituted with C1-6 alkyl, C1-6 alkoxy, hydroxy-C1-6 alkyl, (C1-6) alkoxy-(C1-alkyl) -6), (C1-6) alkoxy (C1-6) alkoxy, C1-6 alkylcarbonyl, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 mono-alkylamino, C1- di-alkylamino 6, C1-6 alkylcarbonylamino, C1-6 alkylcarbonyl - (C1-6 alkyl) amino, C2-6 alkenyl, C3-6 alkenyloxy, C3-6 hydroxy-alkenyl, (C1-6) alkoxy-C2- alkenyl 6), (C1-6) alkoxy (C3-6) alkenyloxy, C2-6 alkenylcarbonyl, C2-6 alkenylthio, C2-6 alkenylsulfinyl, C2-6 alkenylsulfonyl, mono- or di-C2-6 alkenylamino, (C1 -6) - (C3-6 alkenyl) amino, C2-6 alkenylcarbonylamino, C2-6 alkenylcarbonyl - (C1-6 alkyl) amino, C2-6 alkynyl, C3-6 alkynyloxy, C3-6 alkyloxy, alkoxy (C1-6) -C3-6 alkynyl, (C1-6) alkoxy-C4-6 alkyloxy, C2-6 alkynylcarbonyl, C2-6 alkynylthio, C2-6 alkylsulfinyl, C2-6 alkylsulfonyl, mono- or di-alkylamino C3-6, (C1-6) alkyl - (C3-6 alkynyl) amino, C2-6 alkynylcarbonylamino, or with (C2-6) alkynylcarbonyl - (C1-6 alkyl) amino; and / or the phenyl ring, the naphthyl ring and the 5- or 6-membered aromatic ring may be substituted with C1-6 alkyl, C1-6 alkoxy, hydroxy-C1-6 alkyl, (C1-6) alkoxy-(C1-alkyl) -6), (C1-6) alkoxy (C1-6) alkoxy, C1-6 alkylcarbonyl, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 mono-alkylamino, C1- di-alkylamino 6, C1-6 alkylcarbonylamino, C1-6 alkylcarbonyl - (C1-6 alkyl) amino, C2-6 alkenyl, C3-6 alkenyloxy, C3-6 hydroxy-alkenyl, (C1-6) alkoxy-C2- alkenyl 6), (C1-6) alkoxy (C3-6) alkenyloxy, C2-6 alkenylcarbonyl, C2-6 alkenylthio, C2-6 alkenylsulfinyl, C2-6 alkenylsulfonyl, mono- or di-C2-6 alkenylamino, (C1 -6) - (C3-6 alkenyl) amino, C2-6 alkenylcarbonylamino, C2-6 alkenylcarbonyl - (C1-6 alkyl) amino, C2-6 alkynyl, C3-6 alkynyloxy, C3-6 alkyloxy, alkoxy (C1-6) -C3-6 alkynyl, (C1-6) alkoxy-C4-6 alkyloxy, C2-6 alkynylcarbonyl, C2-6 alkynylthio, C2-6 alkylsulfinyl, C2-6 alkylsulfonyl, mono- or di-alkylamino C3-6, (C1-6) alkyl - (C3-6 alkynyl) amino, C2-6 alkynylcarbonylamino, or (C2-6) alkynylcarbonyl - (C1-6 alkyl) amino, halo-substituted; and / or the phenyl ring, the naphthyl ring and the 5 or 6-membered aromatic ring may be substituted with a radical of the formula COOR50, CONR51, SO2NR53R54 or SO2OR55, where each of the R50, R51, R52, R53, R54 and R55, independently of the others, is C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl; or C1-6 alkyl, C2-6 alkenyl or C3-6 alkynyl substituted with halo, hydroxy, alkoxy, mercapto, amino, cyano, nitro, alkylthio, alkylsulfinyl or alkylsulfonyl; and n is 0, 1 or 2, by reacting a compound of the formula (2), in which: R0, R1, R2, R3 and n are as defined above and X is a leaving group, with acid dinitrile malonic in an inert diluent in the presence of a palladium catalyst and a base, wherein said process comprises the use of an alkali metal hydroxide or a mixture of alkali metal hydroxides as a base. |
| priorityDate | 2002-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.