http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-042115-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2003-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c9d757acd07aece5d55a6d7a250d99e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5056f813bb112f74ffabbf37735239d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83b930cbf38f95f28f10b96a823f8662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73d0815be70ad289067b52570037f574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dad4b9f0b9fb925b3ccca3a905174fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_710812dee27521a0d71c94863717d373 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_094c8562a22744ef3f593f25c3a7cd7d |
| publicationDate | 2005-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-042115-A1 |
| titleOfInvention | CARBOXILIC ACID AMIDAS |
| abstract | The new compounds of the formula (1), where: D is an unsubstituted aromatic carbo- or heterocycle or mono or polysubstituted by Hal, A, OR2, N (R2) 2, NO2, CN, COOR2 or CON (R2) with 0 at 4 atoms of N, O and / or S; X is -C = O or C (R3) 2; W is - [C (R3) 2] n-; R1 is H or A which may be substituted by OR3, S (O) nR3, N (R3) 2, CN, COOR3, CON (R3) 2, OCON (R3) 2, N (R3) COOR3, N (R3) CON (R3) 2, N (R3) SO2R3, SO2N (R3) 2 or -C ::: C-; R2 is H, A, - [C (R3) 2] n-Ar ', - [C (R3) 2] n-Het1, - [C (R3) 2] n-cycloalkyl, - [C (R3) 2 ] nN (R3) 2 or - [C (R3) 2] n-OR3; R3 is H or A; Y is alkylene, cycloalkylene, Het-diyl or Ar-diyl; T is a saturated, unsaturated or aromatic mono- or bicyclic carbo- or heterocycle with 0 to 4 atoms of N, O and / or S, which is mono or disubstituted by = O, = S, = NR2, = N-CN, = N-NO2, = NOR2, = NCOR2, = NCOOR2, = NOCOR2 and can also be mono, di or trisubstituted by R2, Hal, A, - [C (R3) 2] n-Ar, - [C (R3) 2 ] n-Het, - [C (R3) 2] n-cycloalkyl, OR2, N (R2) 2, NO2, CN, COOR2, CON (R2) 2, NR2COA, NR2CON (R2) 2, NR2SO2A, COR2, SO2NR2 and / or S (O) nA; A is C1-10 unbranched or branched alkyl, where one or two CH2 groups can be replaced by O or S atoms and / or by groups -CH = CH and / or 1-17 H atoms can be replaced by F; Ar is phenyl, naphthyl or unsubstituted or mono, di or trisubstituted by Hal, A, OR2, N (R2) 2, NO2, CN, COOR2, CON (R2) 2, NR2COA, NR2CON (R2) 2, NR2SO2A, COR2 , SO2N (R2) 2, S (O) nA, - [C (R3) 2] n-COOR2 or -O- [C (R3) 2] o-COOR2; Ar 'is unsubstituted or mono, di or trisubstituted phenyl by Hal, A, OR3, N (R3) 2, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3CON (R3) 2, NR3SO2A, COR3, SO2N ( R3) 2, S (O) nA, - [C (R3) 2] n-COOR3 or -O- [C (R3) 2] or-COOR3; Het is a saturated, unsaturated or aromatic mono or bicyclic heterocycle with 1 to 4 atoms of N, O and / or S, which may be unsubstituted or mono, di or trisubstituted by carbonyl oxygen, = S, = N (R2) 2, Hal, A, - [C (R3) 2] n-Ar, - [C (R3) 2] n-Het ', - [C (R3) 2] n-cycloalkyl, - [C (R3) 2 ] n-OR2, - [C (R3) 2] nN (R3) 2, NO2, CN, - [C (R3) 2] n-COOR2 ', - [C (R3) 2] n-CON (R2) 2, - [C (R3) 2] n-NR2COA, NR2CON (R2) 2, - [C (R3) 2] n-NR2SO2A, COR2, SO2NR2 and / or S (O) nA; Het 'is a saturated, unsaturated or aromatic mono or bicyclic heterocycle with 1 to 4 atoms of N, O and / or S that may be unsubstituted or mono or disubstituted by carbonyl oxygen, = S, = N (R3) 2, Hal, A, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3CON (R3) 2, NR3SO2A, COR3, SO2NR3 and / or S (O) nA; Hal is F, Cl, Br or I; m is 1 or 2; n is 0, 1 or 2; or is 1, 2 or 3; as well as its derivatives, solvates and stereoisomers of pharmaceutical utility, including mixtures in all proportions. They are inhibitors of coagulation factor Xa and can be used for the prophylaxis and / or therapy of thromboembolic diseases and for the treatment of tumors. |
| priorityDate | 2002-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.