http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-042085-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-12 |
| filingDate | 2003-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-042085-A1 |
| titleOfInvention | PIRAZINE COMPOUNDS AS CRF MODULATORS |
| abstract | Pyrazine derivatives, pharmaceutical compositions containing them and methods for using them to treat a disorder or condition are described, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as an anxiety-related disorder or an affective disorder. Claim 1: A compound of formula (1) or stereoisomeric forms thereof, or mixtures of stereoisomeric forms thereof, pharmaceutically acceptable drugs thereof or pharmaceutically acceptable salt forms thereof, wherein in formula (1) X is selected of a modified monocyclic group, arylcycloalkyl, substituted arylcycloalkyl, heteroarylcycloalkyl, substituted heteroarylcycloalkyl, arylheterocycloalkyl, substituted arylheterocycloalkyl, substituted heteroarylcycloalkyl or heteroarylcycloalkyl N (where the bonding point is C); The modified monocyclic group is selected from cycloalkyl, aryl, heterocycloalkyl, heteroaryl which is substituted with Y or (CRbRb) nZ, wherein Y is selected from -CN, -NO2, -C (O) Ra, -C (S) Ra, -C (O) ORa, -C (S) ORa, -C (O) NRaRa, -C (S) NRaRa, NRaC (O) Ra, NRaC (S) Ra, NRaC (O) NRaRa, NRaC ( S) NRaRa, NRaC (O) ORa, -OC (O) Ra, -OC (S) Ra, -OC (O) NRaRa, -OC (S) NRaRa, S (O) mNRaRa, NRaS (O) mRa, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, cycloalkyl, substituted cycloalkyl, ORc and NHRc; Z is selected from Y, ORa, NRaRa and S (O) mRa; Rb is independently selected from H, alkyl, aryl, heteroaryl, heterocycloalkyl or cycloalkyl optionally substituted with 1-5Rt; Rc is selected from aryl, heteroaryl, heterocycloalkyl or cycloalkyl optionally substituted with 1 to 5 Rt; n is selected from 1-6; and m is selected from 0, 1, and 2; Ar is selected from aryl, substituted aryl, heteroaryl, substituted heteroaryl; R1, R2 are independently selected from H, halogen, -NO2, -CN, -ORa, NRaRa, -C (O) Ra, -C (O) NRaRa, -C (S) NRaRa, -C (O) ORa, -C (S) ORa, S (O) mNRaRa, NRaS (O) mRa, NRaC (O) ORa, NRaC (O) Ra, NRaC (O) NRaRa, NRaC (S) NRaRa, and -OC (O) NRaRa , OC (O) Ra, OC (O) ORa, CRbRbZRf; Ra is independently selected from H, alkyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocycloalkyl optionally substituted with 1 to 5 of Rt, oxo (= O), thione (= S), phenyl, heteroaryl or heterocycloalkyl, with phenyl being optionally substituted, heteroaryl and heterocycloalkyl with 1 to 5 independently taken from Rt; Rf is independently selected from ethyl, propyl, butyl, pentyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocycloalkyl optionally substituted with 1 to 5 of Rt, oxo (= O), thione (= S), phenyl, heteroaryl or heterocycloalkyl, being optionally substituted phenyl, heteroaryl and heterocycloalkyl with 1 to 5 independently taken from Rt; Rt is independently selected from Rw, halogen, -NO2, NRwRw, -ORw, -SRw, -CN, -C (O) NRwRw, -C (O) Rw, -OC (O) NRwRw, -OC (O) Rw , NRwC (O) Rw, NRwC (O) NRwRw, NRwC (O) ORw, S (O) mRwRw, NRwS (O) mRw, -S (O) 2NRwRw, -NRwS (O) 2NRwRw, and Rw is independently selected of H, alkyl, cycloalkyl, phenyl, benzyl, heteroaryl or heterocycle, with phenyl, benzyl, heteroaryl and heterocycloalkyl being optionally substituted with alkyl or halogen. |
| priorityDate | 2002-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.