http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-042084-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68f2bd3d611c7a2a832128d8430d9193 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B60N2-3031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B60N2-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B60N2-0292 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B60N2-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B60N2-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B60N2-3045 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B60N2-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B60N2-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B60N2-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B60N2-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B60N2-22 |
| filingDate | 2003-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_861dd0c3205e7f5548217faa5a57d13e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7258d28da64ad709d359aede98a1edc0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_458058ada96a0a61493a29ce9bd268dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e9227ef1ae867d0d9cac0f0c414cd78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0da3bc4ff7803173ef0facf2d0ff6eb |
| publicationDate | 2005-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-042084-A1 |
| titleOfInvention | BI-AROMATIC COMPOUNDS ACTIVATORS OF RECEPTORS OF THE PPARY TYPE AND ITS USE IN COSMETIC OR PHARMACEUTICAL COMPOUNDS |
| abstract | Biaromatic compounds that respond to the general formula (1). Its method of preparation, and its use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, as well as in the field of cardiovascular diseases, immune diseases and / or diseases related to the metabolism of lipids), or even in cosmetic compositions. Claim 1: Compounds characterized in that they respond to formula (1) in which R1 represents a halogen atom or an atom of H, R1 represents a radical chosen from among the formulas (a); (b); (c) - (CH2) m- (CO) n- (X) p- (CH2) q-R5; (d) - (CH2) m- (NR16) n- (C (O, NR17)) p-R5, (e) an alpha-amino acid N-protected by classical amine protecting groups, such as 9-fluorenylmethylcarbamate ( FMOC), t-butylcarbamate (BOC), benzyl or trifluoroacetyl; R5, R6, R16, R17, X, m, n, p and q have the meanings given below; R2 represents a radical chosen from the formulas (a2), (b2), (c2), R8, R9, V, W, and Y have the meanings given below; R3 represents an H atom, a halogen atom, an alkyl radical having 1 to 12 C atoms, a hydroxyl radical, an alkoxy radical having 1 to 7 C atoms, a polyether radical, a nitro radical, or an amino radical that may be optionally substituted by one or more alkyl radicals having 1 to 12 C atoms, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; R4 represents a C1-12 alkyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical or a 9-fluorenylmethyl radical; R5 represents an H atom, a C1-12 alkyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical or a group (CO) s (Z) tR7; Z, R7, s, t have the meanings given below; R6 represents an atom of H, a C1-12 alkyl radical; m, n, p, q, s and t can take the values 0, 1, or 2; X represents an atom of O, S or NR7; R7 has the meanings given below; V represents an atom of N, O or S; W represents an N atom or a C-R11 radical; R11 has the meanings given below; Y represents an atom of N or an atom of C; Z represents an atom and O, of N or of S; R7 represents an H atom, a C1-12 alkyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; R8 represents an H atom, a C1-12 alkyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; R9 represents an O- (CH2) v-R10 radical, a hydroxyl radical, a C1-7 alkoxy radical, an aralkoxy radical or an aryloxy radical, an aryl radical, aralkyl radical, a heteroaryl radical, a heterocyclic radical, or the radical shown in the rest of formula (2); R10, R 'and R "have the meanings below; R' represents an atom of H, a C1-12 alkyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical or a hydroxyl radical; R" represents an H atom, a C1-12 alkyl radical, an aryl radical, an aralkyl radical, optionally substituted by one or more halogens, a heteroaryl radical, a heterocyclic radical or a (CH2) v-R10 radical; R10 and v have the meanings given below. R10 represents an aryl, aralkyl, heteroaryl, heterocyclic radical, the NH-CO-R11 radical, the NH-CO-O-R11 radical, the C-R11R12 radical or the CH-R11-R12 radical; v can take the values 1, 2, or 3; R11 represents an H atom, a C1-12 alkyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical; R12 represents an H atom or a C1-3 alkyl radical; A represents a following structure link: - (CH2) z- (N-R13) and- (CO) x- (D) w-, (CH2) z- (N-R13) and- (CS) x- ( D) w; D, w, x, y, z, and R13 have the meanings given below; D represents an atom of O, of S, a radical -NR14 or a radical CH2; R14 has the significance given below; w, x, z, identical or different, can take the values 0 or 1; w can take the values from 0 to 6, and it is understood that w is equal to 0 or 1 when D represents an atom of O, and R13 and R14 represent an atom of H or a C1-12 alkyl radical; R15 represents an H atom or a C1-7 alkyl radical; R16 and R17 independently represent each other, an atom of H, a C1-12 alkyl radical, an aryl radical, an aralkyl radical, a heteroaryl radical or a heterocyclic radical or a hydroxyl radical; and the optical and geometric isomers, pure or in admixture in any proportion of said compounds of formula (1) as well as their salts, except for those derived from the following formula (3), for which R3 = OMe and R´3 = R "3 = H, R3 = OMe, R´3 = OMe and R" 3 = H and R3 = H and R´3 = R "3 = OMe, except for the derivatives of the following formula (4) for which z = 1, yx = 0 and z = 0 and x = 1 and except for the derivatives of the formula (5) for which p = 1, X represents an atom of O, R5 represents a benzyl radical and R4 represents a radical 2-benzimidazole or 4-pyridine; p = 1, x represents an O atom, R5 represents an ethyl radical and R4 represents a 2-pyridine, 3-pyridine, 4-pyridine, methyl radical; p = 1, X represents a O atom, R4 represents a propyl radical and R5 represents an ethyl radical, CH2-isopropyl, CH2-terbutyl, cyclopentyl or 4-methoxyphenyl, benzyl; p = 1, X represents an NH radical, R4 represents a propyl radical and R5 represents a H atom or a benzyl radical; p = 1, X represents an NH radical, R4 and R5 represent a cyclohexyl radical and p = 0, R4 represents an ethyl radical and R5 represents a 4-methoxyphenyl radical. |
| priorityDate | 2002-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 53.