| abstract |
Methods for treating restless legs syndrome or disorders for treating restless legs syndrome or related disorders, which comprises administering an effective amount of at least one A2A adenosine receptor antagonist to a patient in need. Adenosine A2A receptor antagonist is a xanthine derivative or a pharmaceutically acceptable salt thereof. Claim 3: The method of treating restless legs syndrome according to claim 2, wherein the xanthine derivative is presented by the following formula (1), wherein: R1, R2 and R3 independently represent hydrogen, lower alkyl, alkenyl lower or lower alkynyl; R4 represents cycloalkyl, - (CH2) n-R5 (where R5 represents substituted or unsubstituted aryl, or a substituted or unsubstituted heterocyclic group; and n is an integer from 0 to 4); or a formula (2), (where Y1 and Y2 independently represent hydrogen, halogen or lower alkyl; and Z represents substituted or unsubstituted aryl; or a formula (3), (where R6 represents hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro or amino; and m represents an integer between 1 and 3) and X1 and X2 independently represent O or S. |