http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-040891-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_78587acbfc8d4c9e9ac3baa7021087d7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-60 |
| filingDate | 2003-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_840185ec86866229d5110691df9c26f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1b8fd55bb078c306f591d208c2163bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53125e001e8430040250967541124028 |
| publicationDate | 2005-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-040891-A1 |
| titleOfInvention | COMPOSITION WITH MODIFIED GROWTH HORMONE RELEASE HORMONE (GHRH) |
| abstract | An aspect of the present invention is a composition for a modified growth hormone release hormone ("GHRH") or the functional biological equivalent thereof. Another aspect of the present invention includes a nucleic acid molecule encoding modified GHRH or the functional biologic equivalent. The modified GHRH can be defined as a biologically active polypeptide that has been engineered to contain a different amino acid sequence while simultaneously maintaining a similar or improved biological activity compared to the wild-type GHRH polypeptide ('' wt-GHRH '') . Another aspect of the present invention includes a method for releasing a subject from the composition of this invention, wherein modified GHRH increases in a subject the levels of growth hormone secretion ("GH"). The preferred subject is a human being or a domestic animal. In addition, the modified GHRH composition is resistant to degradation compared to wt-GHRH. Claim 1: A composition comprising a modified growth hormone release hormone ('' GHRH '') or a functional biological equivalent thereof with a general formula -A1-A2-DAIFTNSYRKVL-A3-QLSARKLLQDI-A4-A5 -RQQGERNQEQGA-OH where: A1 is a D oL isomer of the amino acid tyrosine ('' Y '') or histidine ('' H ''); A2 and the D or L isomer of the amino acid alanine ('' A ''), valine ('' V ''), or isoleucine ('' I ''); A3 is a D or L isomer of the amino acid alanine ('' A '') glycine ('' G ''); A4 is a D or L isomer of the amino acid methionine ("M"), or leucine ("L"); A5 is a D or L isomer of the amino acid serine ('' S '') or asparagine ('' N ''). |
| priorityDate | 2002-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.