http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-040513-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05ff905fdc49089f5f25746eaeb40190 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2003-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-040513-A1 |
| titleOfInvention | KINASE INHIBITORS |
| abstract | Pyrimidopyrimidines, dihydropyrimidopyrimidines, pyridopyrimidines, naphthyridines and substituted phenyl pyridopyrazines, which inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediates for their synthesis, as well as pharmaceutical compositions and methods for use in treatment, inhibition or prevention are provided of diseases associated with cell proliferation disorders, including angiogenesis, atherosclerosis, restenosis and cancer. Claim 1: A compound of formula (1) characterized in that: A is O, NH2, NH-C1-6 alkyl, N- (C1-6 alkyl) 2 or -NHC (O) -NHR12; R12 is straight or branched chain (C1-6) alkyl, or - (CH2) n-C3-8 cycloalkyl, n is an integer between 1 and 3; B, C and D are independently selected from CH or N with the proviso that C and D are not both N; R1 is selected from the straight or branched chain (C1-6) alkyl group, optionally substituted with -COOH or; a) a phenyl, benzyl, or cycloalkyl (C3-8) or -CH2-cycloalkyl ring (C3-8) ring, with the phenyl, benzyl or cycloalkyl rings being optionally substituted with 1 or 2 COOH or -CH2-COOH groups ; or b) a piperidine or piperazine moiety selected from the group of formula (2) wherein the rings of the piperidine or piperazine moieties being optionally substituted with 1 or 2 COOH or -CH2-COOH groups; or c) a tetrahydropyran or morpholine moiety of formula (3); R2 is H, Cl or F; R3 is H, Cl or F, with the proviso that at least one of R2 or R3 is F; R4 is H, OH, -OCH3, or -OCH2CH3, with the proviso that if R4 is H, R2 and R3 are not H; R5 is -OCH3, or -OCH2CH3; R6 is selected from the group H, -alkyl (C1-5) -NH2, -alkyl (C1-5) -NH-alkyl (C1-3) -R11, -alkyl (C1-5) -N- (alkyl (C1 -3) -R11) 2, O-(C1-5) alkyl -NH2, -O-(C1-5) alkyl -NH-(C1-3) alkyl -R11, -O-(C1-5) alkyl - N- (C1-3 alkyl) -R11) 2, -CH (CH2OH) 2, -C1-3 alkyl - (CH2OH) 2, -C1-3 alkyl -O-C1-3 alkyl -R11, -C1-3alkyl -O-C1-3alkyl -NH2, -C1-3alkyl -O-C1-3alkyl -NH-C1-3alkyl -R11, -C1-3 alkyl-O-C1-3 alkyl-N- (C1-3 alkyl) -R11) 2, phenyl substituted with 1 or 2 groups selected from NH2, -N-C1-3 alkyl, -N ((C1-3) alkyl) 2, CN or (C1-3) alkyl-tetrazol, or (C1-6) alkyl, or a moiety group of formula (4), with each of the alkyl chains of any group in this definition of R4 being optionally substituted with 1 to 4 OH groups; R7 in each case is independently selected from H, NH2, NH-C1-3 alkyl, N- (C1-3 alkyl) 2 or C1-3 alkyl; R8 is H, OH or (C1-3) alkyl; R9 is H, OH, -NH2, NH-C1-3 alkyl, or N- (C1-3 alkyl) 2; R10 is H or (C1-3) alkyl; R11 is H, CN, OH, NH2, F or CF3; or a pharmaceutically acceptable salt or ester form thereof. |
| priorityDate | 2002-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.