| abstract |
Aryl- and heteroarylcarbonylpiperazines compounds of the general formula (1), method of preparation and their use as medicaments, especially for the treatment of tumors. Claim 1: Piperazinylcarbonyl compound substituted by aryl and heteroaryl characterized in that they have the general formula (1), wherein the substituents have the following meaning: R1: fluoren-9-one, isoxazole, cinoline, isothiazole, isoquinoline, 9H-fluorene, 9H -xanthene and 1H-pyrazole, where the binding can be carried out through any possible ring member of the heteroaryl or aryl radical and the aromatic and heteroaromatic substances may be mono or polysubstituted or unsubstituted, R2: O, S; R3: represents one or up to 16 substituents selected from the group: H, unsubstituted or substituted alkyl, halogen, COOH, CONH2, where the substituents may be arranged in the heterocycle in a neighborhood or geminal form; R4: unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted alkylaryl, unsubstituted or substituted alkylhetaryl; m, n: 0-3. |