| abstract |
Compounds of the general formula 1, or salts thereof acceptable for pharmaceutical use, wherein R1 is selected from H, lower alkyl, R4-CO, R4-O2CCH2, R5-OCO and R5-SO2; R2 is selected from lower alkyl, cycloalkyl optionally substituted with an alkyl or alkyloxy group, (C5-12) cycloalkylalkyl optionally substituted with an alkyl or alkyloxy group, aralkyl optionally substituted with up to three groups selected from F, Cl, Br, I, OH , lower alkyl and O- (lower alkyl), O-benzyl, NH2, NO2, NH-acyl, CN and CF3, and optionally substituted aralkyloxymethyl up to three groups selected from F, Cl, Br, OH, lower alkyl and O- ( lower alkyl); or R1 and R2 are together an o-xylylene group, optionally substituted on the aromatic ring with a group selected from F, Cl, Br, OH, lower alkyl and O- (lower alkyl); R3 is selected from H, OH and O-lower alkyl; R4 is selected from H, lower alkyl and phenyl; and R5 is selected from lower alkyl, phenyl and benzyl. The compounds are useful as pharmaceutical compositions. |