| abstract |
Its use as inhibitors of ileal bile acid transport (IBAT) for the treatment of hyperlipidemia. Manufacturing processes and pharmaceutical compositions that contain them. Claim 1: A compound, characterized in that it responds to formula (1) wherein: R1 and R2 are independently selected from C1-4 alkyl; R3 is hydrogen, hydroxy or halo; R4 is C1-4 alkyl optionally substituted by hydroxy, methoxy and methylS (O) where a is 0-2; R5 is hydroxy or HOC (O) CH (R6) NH-; R 6 are selected from hydrogen and C 1-3 alkyl optionally substituted by hydroxy, methoxy and methyl S (O) where a is 0-2; or a salt acceptable for pharmaceutical, solvate, solvate use of said salt or a prodrug thereof; with the proviso that when R1 and R2 are both butyl, R5 is hydroxy and R4 is methylthiomethyl, methylsulfinylmethyl, 2-methylthioethyl, hydroxymethyl, methoxymethyl; R3 is not hydrogen; and with the proviso that when R1 and R2 are both butyl, R5 is HOC (O) CH (R ') NH-, R6 is hydroxymethyl and R4 is hydroxymethyl; R3 is not hydrogen. |