| abstract |
Claim 1: A compound of the formula (1) or a pharmaceutically acceptable salt thereof in which R1 is H, C1-6 alkyl, C2-6 alkanoyl or C7-11 carboarylalkoxy; each of R2 and R3 is, independently H, hydroxy, C1-6 alkyl, C1-6 alkoxy, halogen, carboxamido, C2-6 carboalkoxy, perfluoralkyl C1-6, cyano, C1-6 alkanesulfonamido, C1-6 alkanesulfonyl, C1-6 alkanamide, amino, C1-6 alkylamino, C1-6 dialkylamino per alkyl portion, C1-6 perfluoralkoxy, C2-6 alkanoyloxy, C2-6 alkanoyl, C6-8 aroyl, C5-7 aryl, a C6- alkylaryl group 13 with 5 to 7 C atoms in the aryl portion, a 5-7 membered heteroaryl group or a 6 to 13 member alkylheteroaryl group with 5 to 7 members in the heteroaryl portion, where any R2 or R3 substituent having a portion aryl or heteroaryl may be optionally substituted on the aryl or heteroaryl moiety with 1 to 3 substituents independently selected from a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group; each of R4 and R5 is, independently, H, or C1-6 alkyl R4 and R5, taken together with the C to which they are attached form a cyclic portion selected from a C4-8 cycloalkane, C4-8 cycloalkene, bicyclic alkane forming C5-10 bridge, bicyclic alkene forming C5-10 bridge, pyran or thiopyran, in which the S atom is optionally oxidized to sulfoxide or sulfone, where the cyclic portion formed by R4 and R5 can be optionally substituted with 1 to 3 substituents independently selected from a halogen atom, a C1-6 alkyl group or a C1-6 alkoxy group; each of R6 and R7 is, independently, H, or C1-6 alkyl; n is 1 or 2 and a dotted line represents an optional double bond. |