http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-039450-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4178 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4172 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2003-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73d0815be70ad289067b52570037f574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8f6127bf08d4e73dc162a71c118f529 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dad4b9f0b9fb925b3ccca3a905174fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e82d93548987c332fa6da973b74ed4f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83b930cbf38f95f28f10b96a823f8662 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c9d757acd07aece5d55a6d7a250d99e |
| publicationDate | 2005-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-039450-A1 |
| titleOfInvention | CARBOXAMIDS AS INHIBITORS OF THE XA COAGULATION FACTOR |
| abstract | They are inhibitors of coagulation factor Xa and can be used for the prophylaxis and / or therapy of thromboembolic diseases and for the treatment of tumors. Claim 1: Compounds of the formula (1) wherein: D is phenyl, pyridyl or thienyl, each of which is unsubstituted or monosubstituted or polysubstituted by Hal, A, OR2, N (R2) 2, NO2, CN, COOR2 or CON (R2) 2; X is NR3 or O; R1 is H, Ar, Het, cycloalkyl or A, which may be substituted by OR2, S (O) mR2, N (R2) 2, Ar, Het, cycloalkyl, CN, COOR2 or CON (R2) 2; R2 is H, A, - [C (R3) 2] n-Ar, - [C (R3) 2] n-Het, - [C (R3) 2] n-cycloalkyl, - [C (R3) 2] nN (R3) 2 or - [C (R3) 2] nOR3, R3 is H or A; W is - [C (R3) 2] n-; Y is alkylene, cycloalkylene, Het-diyl or Ar-diyl; T is a saturated, unsaturated or aromatic monocyclic or bicyclic monocyclic or heterocyclic ring having 1 to 4 atoms of N, O and / or S, which is monosubstituted or substituted by = S, = NR2, = NOR2, = NCOR2, = NCOOR2, = NOCOR2, = N-CN or = N-NO2 and which can also be monosubstituted, disubstituted or trisubstituted by Hal, A, - [C (R3) 2] n-Ar, - [C (R3) 2] n-Het, - [C (R3) 2] n-cycloalkyl, OR3, N (R3) 2, NO2, CN, COOR2, CON (R2) 2, NR2COA, NR2CON (R2) 2, NR2SO2A, COR2, SO2NR2 and / or S (O) mA, A is C1-10 unbranched or branched alkyl, where one or two CH2 groups may be replaced by O or S atoms and / or by groups -CH = CH- and / or, in addition, 1-7 atoms of H may be replaced by F; Ar is phenyl, naphthyl or biphenyl, each of which is unsubstituted or mono-substituted, disubstituted or trisubstituted by Hal, A, OR3, N (R3) 2, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3CON ( R3) 2, NR3SO2A, COR3, SO2N (R3) 2, S (O) mA, - [C (R3) 2] n-COOR2 'or -O- [C (R3) 2] or -COOR2'; R2 'is H, A, - [C (R3) 2] n-Ar', - [C (R3) 2] n-Het ', - [C (R3) 2] n-cycloalkyl, - [C (R3 ) 2] nN (R3) 2 or - [C (R3) 2] n-OR3; R2 '' is H, A, - [C (R3) 2] n-AR 'or - [C (R3) 2] n-cycloalkyl, - [C (R3) 2] nN (R3) 2 or - [C (R3) 2] n-OR3; Ar 'is phenyl or benzyl, each of which is unsubstituted or monosubstituted or substituted by Hal or A; Het is a saturated, unsaturated or aromatic monocyclic or bicyclic heterocyclic ring having 1 to 4 atoms of N, O and / or S, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by carbonyl oxygen, = S, = N (R3) 2, Hal, A, - [C (R3) 2] n-Ar, - [C (R3) 2] n-Het1, - [C (R3) 2] n-cycloalkyl, - [C ( R3) 2] n-OR2 ', - [C (R3) 2] nN (R2) 2, NO2, CN, - [C (R3) 2] n-COOR2', - [C (R3) 2] n- CON (R2 ') 2, - [C (R3) 2] n-NR2'COA, NR2'CON (R2') 2, - [C (R3) 2] n-NR2'SO2A, COR2 ', SO2NR2' and / or S (O) mA, Het1 is a saturated, unsaturated or aromatic monocyclic or bicyclic heterocyclic ring having 1 or 2 N, O and / or S atoms, which may be unsubstituted or monosubstituted or disubstituted by carbonyl oxygen , = S, = N (R3) 2, Hal, A, OR2 '', N (R2 '') 2, NO2, CN, COOR2 '', CON (R2 '') 2, NR2''COA, NR2 ' 'CON (R2' ') 2, NR2''SO2A, COR2' ', SO2NR2' 'and / or S (O) mA; Hal is F, Cl, Br or I; n is 0, 1 or 2; m is 0, 1 or 2; or is 1, 2 or 3 and derivatives, solvates and stereoisomers thereof for pharmaceutical use, including mixtures thereof in all proportions. |
| priorityDate | 2002-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 69.