http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-039320-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c76ecadad74a1a35270b3e3a34d60f37 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-737 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-728 |
| filingDate | 2003-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-039320-A1 |
| titleOfInvention | SELECTIVE INHIBITORS OF CICLOOXIGENASA-2 |
| abstract | Selective inhibitors of Cyclooxygenase-2 (COX-2) of formula (1), pharmaceutical compositions containing them, for their medical use, and their preparations. The compounds are particularly useful for treating or relieving inflammation and disorders associated with inflammation, such as, for example, rheumatoid arthritis and osteoarthritis, and for relieving pain, such as, for example, pain associated with surgery or trauma in mammals, preferably felines and dogs. Claim 1: A compound of the formula (19 or a pharmaceutically acceptable salt thereof; wherein X is H, halogen, -NO2, C1-6 alkyl, CF3, C3-8 cycloalkyl, (C1-6) alkyl -O -, (C1-6) alkyl -S-, (C1-6) -SO- alkyl, (C1-6) -SO2- alkyl, (C1-6) alkyl - (C = O) -, aryl (C6- 10) - (C = O) -, heteroaryl (C1-10) - (C = O) -, heterocyclyl (C1-10) - (C = O) -, (C1-6) alkyl -NH- (C = O) -, (C6-10) aryl -NH- (C = O) -, or [(C1-6) alkyl] 2-N-SO2-; Y is H, halogen, -NO2, C1-6 alkyl, CF3, C3-8 cycloalkyl, (C1-6) -O- alkyl, (C1-6) -S- alkyl, (C1-6) -SO alkyl, (C1-6) -SO2- alkyl, (C1-) alkyl 6) - (C = O), aryl (C6-10) - (C = O), heteroaryl (C1-10) - (C = O) -, heterocyclyl (C1-10) - (C = O) -, (C1-6) alkyl -NH- (C = O) -, aryl (C6-10) -NH- (C = O) -, or [(C1-6) alkyl] 2-N-SO2; n is 0 , 1 or 2; Q is a 6-membered divalent heterocycle radical of pyran, piperidine, 1,4-dioxane, morpholine, dithian, thiomorpholine, pyridazine, piperazine, pyridine, pyrimidine, pyrazine, 1,3,5-triazine, or 1,3,5-tritian; R1 is H, halogen or C1-6 alkyl and R2 is C1-6 alkyl or cycle C3-8 alkyl. |
| priorityDate | 2002-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.