http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-038837-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dac022280ec96f54c694eb427655932 |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4174 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-727 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-616 |
| filingDate | 2003-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-038837-A1 |
| titleOfInvention | USE OF INHIBITORS OF THE CHLORIDE / BICARBONATE SODIUM EXCHANGER FOR THE TREATMENT OF THROMBOTIC AND INFLAMMATORY DISORDERS |
| abstract | Inhibitors of sodium-dependent chloride / bicarbonate cell exchangers show an inhibitory effect on von Willebrand factor secretion. Consequently, these inhibitors can be used for the treatment of thrombotic and inflammatory disorders. Use of the compounds of formula (1). Claim 2: The use according to claim 1, wherein at least one compound of formula (1) and / or all stereoisomeric forms of the compound of formula (1) is used as an inhibitor of the sodium-dependent chloride / bicarbonate cell exchanger ) and / or mixtures of these forms in any proportion, and / or the physiologically tolerated salts of the compound of the formula (1) in which the symbols have the following meaning: X is selected from the group of structures (2); R1 is H, C1-8 alkyl, or -CaH2a-phenyl, where the phenyl moiety is unsubstituted or substituted with 1, 2, or 3 identical or different moieties of the series of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR19R20; R19 and R20 independently of each other H or C1-4 alkyl; a = 0, 1 or 2; or R1 is -CbH2b-C1-9 heteroaryl where the heteroaryl moiety is unsubstituted or is substituted with 1, 2 or 3 identical or different moieties of the series of F, Cl, Br, I, CF3, CH3, methoxy, hydroxy or NR21R22; R21 and R22 independently of each other are H or C1-4 alkyl; and b = 0, 1 or 2 or R1 is -CcH2c-C2-7 cycloalkyl; and c = 0, 1 or 2; R2 and R3 independently of each other are H, F, Cl, Br, I, CF3, -CN, -NO2, CH2OR23, CO-R24 or O-R25; R23 is H or C1-8 alkyl, R24 is H, C1-8 alkyl, OR26 or phenyl: where phenyl is unsubstituted or substituted with 1, 2, or 3 identical or different radicals of the group of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR27R28; R27 and R28 independently of each other are H, or C1-4 alkyl, R26 is H or C1-8 alkyl; R25 is H, C1-8 alkyl, or phenyl; wherein the phenyl is unsubstituted or substituted with 1, 2, or 3 identical or different radicals of the series of F, Cl, Br, I, CF3, methyl, methoxy, hydroxy or NR29R30; R29 and R30, independently of one another, are H, C1-4 alkyl or R25 is C1-9 heteroaryl, which is unsubstituted or substituted with 1, 2, or 3 identical or different radicals of the series of F, Cl, Br, I, CF3, CH3, methoxy, hydroxyl or NR31R32; R31 and R32 independently of each other are H, or C1-4 alkyl or R2 and R3, independently of each other, are C1-8 alkyl, C3-7 cycloalkyl; or -CdH2d-phenyl, where the phenyl moiety is unsubstituted or substituted with 1, 2, or 3 identical or different radicals of the F, Cl, Br, I, CF3, methoxy, methyl, hydroxyl or NR33R34 series; R33 and R34, independently of one another, are H or C1-4 alkyl; d = 0, 1 or 2, or R2 and R3 independently of each other, are -CeH2e-C1-9 heteroaryl, where the heteroaryl moiety is unsubstituted or is substituted with 1, 2 or 3 identical or different radicals, of the series of F, Cl, Br, I, CF3, CH3, methoxy, hydroxyl or NR35R36; R35 and R36, independently of one another, are H or C1-4 alkyl, e = 0, 1 or 2; or R2 and R3, independently of one another, are -SOf-R37; R37 is C1-8 alkyl, C3-7 cycloalkyl, or -CgH2g-phenyl in which the phenyl moiety is unsubstituted or substituted with 1, 2 or 3 identical or different radicals, of the series of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR38R39; R38 and R39, independently of one another, are H or C1-4 alkyl; f = 0, 1 or 2; g = 0, 1 or 2; R4 is H, C1-8 alkyl, 1-naphthyl, 2-naphthyl, -CiH2i-C3-7 cycloalkyl or CiH2i-phenyl, where the phenyl moiety is unsubstituted or substituted with 1, 2 or 3 identical or different radicals of C1-8, F, Cl, Br, I, CF3, SOjR48, OR49, NR50R51, -CN, -NO2 or CO-R52 alkyl series; i is 0, 1 or 2; R48 is C1-4 alkyl or NR53R54; R53 and R54, independently of one another, are H or C1-4 alkyl; j is 0, 1 or 2; R49 is H, or C1-4 alkyl; R50 and R51, independently of one another, are H or C1-4 alkyl; R52 is H, C1-8 alkyl or OR55; R55 is H, C1-8 alkyl; or R4 and R6 together with the C atom that carries them, C3-7 cycloalkyl, or fluorophenyl; R5, R6, R7 and R8, independently of each other, are H, F, CF3, O-R56, C1-8 alkyl, C3-7 cycloalkyl, -CkH2k-phenyl, in which the phenyl moiety is unsubstituted or is substituted with 1, 2 or 3 identical or different radicals, of the series of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR57R58; R57 and R58, independently of each other are, H, or C1-4 alkyl; k is 0, 1 or 2; R56 is H, C1-8 alkyl or phenyl that is unsubstituted or substituted with 1, 2 or 3 identical or different radicals of the F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR59R60 series; R59 and R60, independently of one another, are H or C1-4 alkyl or R56 is C1-9 heteroaryl, which: is unsubstituted or substituted with 1, 2 or 3 radicals, identical or different from the series of F, Cl , Br, I, CF3, CH3, methoxy, hydroxyl or NR61R62; R61 and R62, independently of one another, are H, or C1-4 alkyl, or R5 and R7 are together a second bond between the C atoms that carry the radicals R6 and R8, where R4, R6 and R8 are as defined above; R9 is C1-8 alkyl, C2-8 alkenyl, or ClH2l-ll-A; ll is 0 or 2; and l is 0, 1, 2, 3, or 4; where l is not 0 or 1 when ll is 2; R10 is H; C1-8 alkyl, or C2-8 alkenyl; -CmH2m-mm-B, mm is 0 or 2; and m is 0, 1, 2, 3 or 4; where m is not 0 or 1 when mm is 2; R11 and R12 independently of each other, are H, C1-8 alkyl, Z is carbonyl or sulfonyl; A and B, independently of each other, are; 1) C6-14 aryl, preferably phenyl, 1-naphthyl or 2-naphthyl; 2) a radical as defined in (1), which is substituted with 1, 2 or 3 radicals, identical or different, of the C1-8 alkyl series, F, Cl, Br, I, CF3, SOnR63, OR64, NR65R66, -CN, -NO2 or CO-R67; 3) C1-9 heteroaryl; 4) a radical as defined in (3), which is substituted with 1, 2 or 3 identical or different radicals of the series of F, Cl, Br, I, CF3, CH3, methoxy, hydroxyl or NR68R69; 5) C3-7 cycloalkyl; 6) O-R70; or 7) O-R71; n is 0, 1 or 2; R70 and R71 independently of one another, are 1) H, 2) C1-8 alkyl, 3) -CoH2o-oo-phenyl, oo is 0 or 2; and o is 0,1,2, 3 or 4; where or is not 0 or 1 when oo is 2; 4) a radical as defined in 3, wherein the phenyl moiety is substituted with 1, 2 or 3 radicals, identical or different, of the C1-8 alkyl series, F, Cl, Br, I, CF3, SOpR72 , OR73, NR74R75, -CN, -NO2 or CO-R76; or 5) C2-8 alkenyl; R63 and R72, independently of one another, are C1-4alkyl or NR77R78; R67 and R76, independently of one another, are H, C1-8 alkyl or OR89; R89 is H or C1-8 alkyl; R64, R65, R66, R68, R69, R73, R74, R75, R77 and R78, independently of each other, are H or C1-4 alkyl; p independently of another is 0, 1, or 2; R13, R14 and R15, independently of each other are H, C1-8 alkyl, F, Cl, Br, I, CF3, -CN, -NO2, SOq-R79, CO-R80 or O-R81; q independently of another is 0, 1 or 2; R79 is C1-8 alkyl or phenyl that is unsubstituted or substituted with 1, 2 or 3 identical or different radicals of the F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR82R83 series; R82 and R83, independently of each other are H or C1-4 alkyl; R80 is H, C1-8 alkyl or OR84; R84 is H or C1-8 alkyl, R81 is H, C1-8 alkyl or phenyl that is unsubstituted or substituted with 1, 2 or 3 radicals identical or different from the series of F, Cl, Br, I, CF3, methyl, methoxy, hydroxyl or NR82R83; Y is a covalent bond, CR16R17, CO, S, SO2, O or NR18, R16 is H or -OR85; R85 is H, C1-8 alkyl or CO-R86; R86 is C1-8 alkyl or phenyl which is unsubstituted or substituted with 1, 2, or 3 radicals, identical or different, of the series of F, Cl, Br, I, CF3, methyl, methoxy or hydroxyl; R17 is H or C1-8 alkyl; R18 is H, C1-8 alkyl, CO-R87 or SO2R88; R87 and R88, independently of one another, are C1-8 alkyl, C3-8 cycloalkyl or phenyl which is unsubstituted or substituted with 1, 2, or 3 identical or different radicals, of the series of F, Cl, Br, I, CF3, methyl, methoxy or hydroxyl. |
| priorityDate | 2002-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 91.