| abstract |
Claim 1: A pharmaceutical composition suitable for topically administered to the eye, characterized in that it comprises: (a) an antibiotic drug in an effective concentration for the treatment and / or prophylaxis of infections caused by gram-positive bacteria in at least one tissue of the eye; (b) a cyclodextrin compound acceptable for pharmaceutical use, with a concentration of cyclodextrin sufficient to keep the drug in solution; and (c) cetyl pyridinium chloride. Claim 2: The composition of claim 1, characterized in that the antibiotic drug is an oxazolidinone antibiotic drug and the bacterial infection is an infection by gram-positive bacteria. Claim 3: The composition of claim 2, characterized in that the oxazolidinone antibiotic drug is a compound of formula (1), wherein: R1 is selected from groups (a) H, (b) C1-8 alkyl optionally substituted with at least a group F, Cl, OH, C 1-8 alkoxy and acyloxy or C 1-8 benzoxy, including a C 3-6 cycloalkyl group, (c) amino, (d) mono and di (C 1-8 alkyl) amino and (e) C1-8 alkoxy; R2 and R3 are each independently selected from H, F and Cl; R4 is H or CH3; R5 is selected from groups H, CH3, CN, CO2R1 and (CH2) mR6, where R1 is as previously defined, R6 is selected from groups H, OH, OR1, OCOR1, NHCOR1, amino, mono, and di (C1 -8 alkyl) amino, and m is 1 or 2; n is 0, 1 or 2; and X is O, S, SO, SO2, SNR7 or S (O) NR7, where R7 is selected from groups H, C1-4 alkyl (optionally substituted with one or more groups F, Cl, OH, C1-8 alkoxy, amino, mono or di (C1-8alkyl) amino) and p-toluenesulfonyl; or a salt thereof acceptable for pharmaceutical use. |