http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-038055-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afc5d8c9ee6673323cee3e2d19bc5146 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C43-1786 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-757 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-178 |
| filingDate | 2002-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-038055-A1 |
| titleOfInvention | PROCESS TO PREPARE 2- (REPLACED PHENYLL) - 2 - HYDROXY - ETIL CARBAMATES. |
| abstract | It refers to a new process for preparing 2- (substituted phenyl) -2-hydroxy-ethyl carbamates and novel intermediates used in this process. It also refers to polymorphic forms of said carbamates and processes to prepare said polymorphic forms. Claim 1. A process for preparing a compound of formula (1) in which: R is halogen, R1 and R2 are independently halogen or C1-4 alkyl, optionally substituted with phenyl or substituted phenyl, wherein the substituted phenyl has substituents selected from halogen, C1-4 alkyl, C1-4 alkyloxy, amino, nitro and cyano; characterized by a) reduction of an ester of the formula (2) in which P is an appropriate alcohol protecting group; R3 is C1-4 alkyl; with an appropriate ester reducing agent to alcohol, thereby obtaining an alcohol of formula (3), b) reacting the alcohol of formula (3) with a carbonyl compound of formula (4) in which X and Y are suitable leaving groups ; and subsequently with an amine of formula (5) thus obtaining a compound of formula (6) C9 elimination of the protective group P, thus obtaining a compound of formula (1). v |
| priorityDate | 2001-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.