http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-037936-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-357 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-357 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 |
| filingDate | 2002-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-037936-A1 |
| titleOfInvention | AMINOINDAN COMPOUNDS AS INHIBITORS OF THE ABSORPTION OF SEROTONINE AND NOREPINEFRINE, PHARMACEUTICAL COMPOSITIONS AND THE USE OF SUCH COMPOUNDS FOR THE PREPARATION OF MEDICINES |
| abstract | An aminoindane compound of the formula (1), in which: X is -O-, -S- or -CR4R5-; Y is -CR6R7-, -CR6R7-CR8R9- or -CR6 = CR7-; or X and Y together form a group -CR4 = CR5, or, -CR4 = CR5-CR6R7; and U is -O-, -S- or CR10R11; or is -O-, -S- or -CR4R5-; and Y is U together form a group CR6 = CR7-, -CR6 = CR7-CR10CR11-, or, -CR6R7-CR10 = CR11-; or, X, Y and U, together, form -CR4 = CR5-CR6 = CR7-; R1 and R2 are independently from each other selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, or, R1 and R2 together with the nitrogen atom at which are attached, form a saturated ring of 3 to 7 members that optionally contains another heteroatom; R13, R14, R15 and R16, are each and independently of each other, selected from the group consisting of hydrogen, halogen, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl , and C3-6 cycloalkyl; R is hydrogen, C1-6 alkyl, or cyano; R4, R5, R6, R7, R8, R9, R10 and R11 are each and independently of each other, selected from the group consisting of hydrogen and C1-4 alkyl; or an acid addition salt thereof. These compounds have the combined effect of inhibiting the reabsorption of serotonin and the absorption of norepinephrine. Pharmaceutical compositions and the use of a pharmaceutically acceptable compound or salt thereof obtained by the addition of an acid, for the preparation of a medicament for the treatment of affective disorders such as depression and disorders of the drug are also described. anxiety, which include general anxiety disorder, social anxiety disorder, post-traumatic stress disorder, obsessive compulsion disorder, panic disorder, panic attacks, specific phobias, social phobia and agoraphobia. |
| priorityDate | 2001-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.