http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-037631-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-24 |
| filingDate | 2002-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_414428c01750ceccca9f9019fab39872 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80c62fb5db5e8394f97b4f97f227b66e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28b123deb0a1abac705e801ccce8e59e |
| publicationDate | 2004-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-037631-A1 |
| titleOfInvention | USE OF 1-PHENYLOXAZOLIDIN-2-ONAS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE THERAPY AND / OR PROFILAXIS OF DISEASES ASSOCIATED WITH AN INCREASED EXPRESSION OF PROTEASE M, AS WELL AS THE NEW 1-PHENYLOXAZOLIDIN-2-ONES, ITS USE AND COMPOSITIONS THAT CONTAIN THEM |
| abstract | The use of the 1-phenyloxazolidin-2-ones of formula (1) is described, wherein: R represents phenyl, naphthyl or Het1, each being unsubstituted or monosubstituted, disubstituted or trisubstituted with A, Ar, (CH2 ) nAr, OR2, OAr, OCF3, OCOR3, CF3, N (R2) 2, NHAr, Hal, NO2, CN, (CH2) nCOOR2, (CH2) nCOOAr, (CH2) nCONHA, (CH2) nCONH-cycloalkyl, ( CH2) nCONA2, (CH2) nCONH (CH2) mAr, COR2, COAr, SA, S (= O) A, SO2A, SAr, S (= O) Ar, SO2Ar, NHCOA, NHCOAr, NHSO2A, NHSO2Ar and / or a rest of formula (2); R1 represents H2N-C (= NH) -; R2 represents H, A, phenyl or benzyl; Ar represents cycloalkyl, phenyl, naphthyl, indanyl 1 or Het2, each being unsubstituted or monosubstituted, disubstituted or trisubstituted with A, OR2, OCF3, CF3, N (R2) 2, Hal, NO2, CN, (CH2) nCOOR2, CON (R2) 2, COR2, SA, S (= O) A, or NHCOA; Het1 represents an aromatic, monocyclic or bicyclic heterocyclic radical, containing from 1 to 4 atoms of N, O and / or S; Het2 represents an aromatic, monocyclic or bicyclic heterocyclic radical, containing 1 to 4 atoms of N, O and / or S; A represents alkyl of 1 to 8 carbon atoms; Hal represents F, Cl, Br or I; m is 0, 1, 2 or 3; n is 0, 1, 2, 3, or 4, its stereoisomers and / or its physiologically acceptable salts or solvates, for the preparation of a medicament for the therapy and / or prophylaxis of diseases associated with a increased expression of protease M. Also described are new 1-phenyloxazolidin-2-ones and their use as inhibitors of integrin and / or as inhibitors of protease M. |
| priorityDate | 2001-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.