| abstract |
Claim 1: An indolinone compound, characterized in that it has the formula (1) and pharmaceutically acceptable salts thereof, in which: R1 is H or alkyl; R2 is O or S; R3 is hydrogen; R4, R5, R6 and R7 are each and independently from each other, selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S (O) R, SO2NRR ', SO3R, SR, NO2, NRR', OH, CN, C (O) R, OC (O) R, NHC (O) R; (CH2) nCO2R, and CONRR '; R3 ', R5' and R6 ', are each and independently of each other, selected from the group consisting of hydrogen, alkyl, alkoxy, aryl, aryloxy, alkaryl, alkaryloxy, halogen, trihalomethyl, S (O) R, SO2NRR ', SO3R, SR; NO2, NRR ', OH, CN, C (O) R, OC (O) R, NHC (O) R, (CH2) nCO2R, and CONRR', n is 0-3; X is Br, Cl, F or I; R is H, alkyl or aryl; and R 'is H, alkyl or aryl. |