| abstract |
Compound of general formula (1), wherein: R is phenyl, pyridin-2-yl, -C (O) -O-lower alkyl, -C (O) -alkyl, -C (O) -morpholinyl, - C (O) -NR'2, - (CH2) n-NR'2 or - (CH2) nO-lower alkyl, and R 'can be hydrogen or lower alkyl; and acceptable pharmaceutical addition salts thereof. The compounds described herein have a good affinity to the A2A receptor and therefore can be used in the control or prevention of diseases based on the modulation of the adenosine system, such as Alzheimer's disease, Parkinson's disease, Huntington's disease , neuroprotection, schizophrenia, anxiety, pain, respiratory deficits, depression, drug addiction, such as amphetamine, cocaine, opioids, ethanol, nicotine, cannabinoids, or against asthma, allergic responses, hypoxia, ischemia, attacks, and abuse of substances In addition, the compounds may be useful as sedatives, muscle relaxants, antipsychotics, antiepileptics, anticonvulsants and cardioprotective agents for disorders such as coronary artery disease and heart failure. |