http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-037394-A1
Outgoing Links
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| filingDate | 2002-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82ac47848137c22e71e3c6cf4775ab4f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e8a66b082133ca1635d097a2195602f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c9d577e929c4a22cfb67e4aaf557c8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70aac6a07e9ebd8704f738d4616688cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c32a977ffcecc53e8c23a8b9d77bf4fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_326ff7140701ed352a7d318a744cf5ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c1a1a3571255b859867be4556e80310 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c39b5e96952c1938b8f0c94f6e7d4d90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8b7b6715146dabb1040a5c4c0aebc0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79b321e500751a488d95c88e57aceac2 |
| publicationDate | 2004-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-037394-A1 |
| titleOfInvention | CHEMIOKIN RECEIVER ANTAGONISTS AND THEIR METHODS OF USE |
| abstract | Compounds, pharmaceutical compositions, prodrugs and methods for treating or preventing the recruitment and / or activation of aberrant leukocytes. A compound having the formula (1) or its physiologically acceptable salt, where: n is 1 to 4; M is> NR2 or> CR1R2; R1 is -H, -OH, -N3, a halogen, an aliphatic group, a substituted aliphatic group, an aminoalkyl group, -O- (aliphatic group), -O- (substituted aliphatic group), -SH, -S- (aliphatic group), -S- (substituted aliphatic group), -OC (O) - (aliphatic group), -OC (O) - (substituted aliphatic group), -C (O) O- (aliphatic group), - C (O) O (substituted aliphatic group), -COOH, -CN, -CO-NR3R4, -NR3R4 or R1 is a covalent bond between ring atom in position M and an adjacent carbon atom of the ring containing M; R2 is -OH, a halogen, an acyl group, a substituted acyl group, -NR5R6, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a heterocyclic group non-aromatic, a substituted non-aromatic heterocyclic group, -O- (substituted or unsubstituted aromatic group), -O- (a substituted or unsubstituted aliphatic group), -C (O) - (substituted or unsubstituted aromatic group) or -C (O) - (a substituted or unsubstituted aliphatic group); R3, R4, R5 and R6 are independently -H, an acyl group, a substituted acyl group, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a group non-aromatic heterocyclic or a substituted non-aromatic heterocyclic group; or R1 and R2, R3 and R4, or R5 and R6 together with the atom to which they bind, form a substituted or unsubstituted unsubstituted carbocyclic or heterocyclic ring; R70 and R71 are independently -H, -OH, -N3, a halogen, an aliphatic group, a substituted aliphatic group, an aminoalkyl group, -O- (aliphatic group), -O- (substituted aliphatic group), -SH, -S- (aliphatic group), -S- (substituted aliphatic group), -OC (O) - (aliphatic group), -OC (O) - (substituted aliphatic group), -C (O) O- (aliphatic group ), -C (O) O- (substituted aliphatic group), -COOH, -CN, -CO-NR3R4, -NR3R4, an acyl group, a substituted acyl group, a benzyl group, a substituted benzyl group, a heterocyclic group non-aromatic, a substituted non-aromatic heterocyclic group, -O- (substituted or unsubstituted aromatic group); R72 and R73 are independently -OH, -N3, a halogen, an aliphatic group, a substituted aliphatic group, an aminoalkyl group, -O- (aliphatic group), -O- (substituted aliphatic group), -SH, -S- (aliphatic group), -S- (substituted aliphatic group), -OC (O) - (aliphatic group), -OC (O) - (substituted aliphatic group), -C (O) O- (aliphatic group), - C (O) O- (substituted aliphatic group), -COOH, -CN, -CO-NR3R4, -NR3R4, an acyl group, a substituted acyl group, a benzyl group, a substituted benzyl group, a substituted non-aromatic heterocyclic group , a substituted non-aromatic heterocyclic group, -O- (substituted or unsubstituted aromatic group); Z is a remainder of formula (2); X1 is -CH2-O-, -O-CH2-, -S-, -CH2-, CH2-CH2-, -CH2-S-, -S-CH2-, -NRc-CH2-, -CH2-NRc, -SO-CH2-, -CH2-SO-, -S (O) 2-CH2-, -CH2-S (O) 2-, -CH = CH-, -NRc, a bond, -O-, or - CO-NRc-; Rc is -H, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group or a substituted benzyl group; rings A and B are independently unsubstituted or substituted; said acyl group is an aliphatic carbonyl, aromatic carbonyl, aliphatic sulfonyl or aromatic sulfonyl; said aliphatic group is a C1-6 alkyl, alkenyl or alkynyl; said aromatic group is selected from the group consisting of phenyl, 1-naphthyl, 2-naphthyl, 1-anthracil, 2-anthracil, N-imidazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl, 2-thienyl, 3- thienyl, 2-furanyl, 3-furanyl, 2-pyrrolyl, 3-pyrrolyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 3-pyridazinyl, 4-pyridazinyl, 3-pyrazolyl, 4-pyrazolyl, 5-pyrazolyl, 2-pyrazinyl, 2-thiazolyl, 4-thiazolyl, 5-thiazolyl, 5-tetrazolyl, 2-oxazolyl, 4-oxazolyl, 5-oxazolyl, tetrahydranaphthyl, 2-benzothienyl, 3-benzothienyl, 2-benzofuranyl, 3-benzofuranyl, 2-indolyl, 3-indolyl, 2-quinolinyl, 3-quinolinyl, 2-benzothiazolyl, 2-benzooxazolyl, 2-benzimidazolyl, 1-isoquinolinyl, 3-quinolinyl, 1- isoindolyl, 3-isoindolyl, acridinyl, 3-benzisoxazolyl, benzocyclopentyl, benzocyclohexyl; said non-aromatic heterocyclic group is a 5- to 8-membered, non-aromatic ring, which contains one or more heteroatoms independently selected from the group consisting of nitrogen, oxygen or sulfur; said substituted aliphatic group is substituted with one or more substituents selected from the group consisting of the oxo group, the epoxy group, a non-aromatic heterocyclic ring, benzyl group, substituted benzyl group, aromatic group or substituted aromatic reducing group, halo, azido, -CN, -CONR24R25, -NR24R25, -OS (O) 2NR24R25, -S (O) 2NR24R25, -SO3H, guanidino, oxalo, -C (= NR60) NR21R22, = NR60, - (O) or- (CH2) tC (O) OR20, - (O) u- (CH2) t-OC (O) R20, - (O) u- (CH2) tC (O) -NR21R22, - (O) u- (CH2) t- NHC (O) O-R20, -QH, -Q- (aliphatic group), -Q- (substituted aliphatic group), -Q- (aryl), -Q. (Aromatic group), -Q- (substituted aromatic group ), -Q- (CH2) p- (substituted or unsubstituted aromatic group), -Q- (non-aromatic heterocyclic group) or -Q- (CH2) p- (non-aromatic heterocyclic group); said substituted non-aromatic heterocyclic ring is substituted with one or more substitutes selected from the group consisting of = O, = S, reducer, halo azido, -CN, -CONR24R25, -NR24R25, -OS (O) 2NR24R25, -S (O ) 2NR24R25, SO3H, guanidino, oxalo, -C (= NR60) NR21R22, = NR60, - (O) u- (CH2) tC (O) OR20, - (O) or- (CH2) t-OC (O) R20, - (O) u- (CH2) tC (O) -NR21R22, - (O) u- (CH2) t-NHC (O) O-R20, -QH, -Q- (aliphatic group), -Q - (substituted aliphatic group), -Q- (aryl), -Q- (aromatic group, -Q- (substituted aromatic group), -Q- (CH2) p- (substituted or unsubstituted aromatic group), -Q- (non-aromatic heterocyclic group) or -Q- (CH2) p- (non-aromatic heterocyclic group); said substituted aromatic group, substituted benzyl group, ring A when it is substituted and ring B when substituted, are with one or more substitutes selected from the group consisting of electron reducer, halo, azido, -CN, -CONR24R25, -NR24R25, -OS (O) (O) 2NR24R25, -S (O) (O) 2NR24R25, -SO3H, guanidino, oxalo , C (= NR60) NR21R22, = NR60, - ( O) u- (CH2) tC (O) OR20, - (O) u- (CH2) t-OC (O) R20, - (O) u- (CH2) tC (O) -NR21R22, - (O) u- (CH2) t-NHC (O) O-R20, -QH, -Q- (aliphatic group), -Q- (substituted aliphatic group), -Q- (aryl), -Q- (aromatic group), -Q- (substituted aromatic group), -Q- (CH2) p- (substituted or unsubstituted aromatic group), -Q- (non-aromatic heterocyclic group) or -Q- (CH2) p- (aromatic heterocyclic group); . Q is -O-, -S-; -S (O) -, -S (O) 2-, -OS (O) 2-, -C (O) -, -OC (O) -, -C (O) O-, -C (O) C (O) -O-, -OC (O) C (O) -, -NHC (O) -, -OC (O) NH-, -NH-C (O) -NH-, -S (O) 2NH-, -NHS (O) 2-, -C (NR23) NHNH-, -NHNHC (NR23) -, -NR24C (O) - or -NR24S (O) 2-; R20, R21 and R22 are independently -H, an aliphatic group, an aromatic group, a non-aromatic heterocyclic group, -NHC (O) -O- (aliphatic group), -NHC (O) -O- (aromatic group) or -NHC (O) -O- (non-aromatic heterocyclic group) or R21 and R22, together with the nitrogen atom to which they are attached, can form a substituted or unsubstituted non-aromatic heterocyclic ring; R23 is -H, an aliphatic group, a benzyl group, a non-aromatic aryl or heterocyclic group; R24 and R25 are independently -H, an aliphatic group, a substituted aliphatic group, a benzyl group, an aryl group, non-aromatic heterocyclic group or R24 and R25 together with the nitrogen atom to which they are attached can form a non-aromatic heterocyclic ring substituted or unsubstituted. R60 is a -H, -OH, -NH2, an aromatic group or a substituted aromatic group; t is 0 to 3; u is 0 or 1; p is 1 to 5. A compound having the formula (3) or its physiologically acceptable salt, where: n is an integer from 1 to 4; M is> NR2,> CR1R2, -O-CR1R2-O- or -CH2-CR1R2-O-; q1 is an integer between 0 to 3; q2 is 0 or 1; R1 and R2 are those already defined above; Z is a remainder of formula (4), A, C, B and X1 are those already defined above and R40 is selected from the group of formulas (5). A compound having the formula (6) or its physiologically acceptable salt, where: Z, n and R2 are those already defined above. |
| priorityDate | 2001-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 144.