| abstract |
Anthranilic acid amide derivatives of the formula (1) wherein Ar is represented by the formula (2) wherein Ra represents H or lower alkyl; R1 represents H or lower perfluoroalkyl; and R2 represents H, halogen, C2-7 alkyl, C2-7 alkenyl, or lower alkynyl; or Ar is represented by sub-formula (3), and R1 represents lower perfluoroalkyl, and R2 represents bromine, iodine, C2-7 alkyl, C2-7 alkenyl, or lower alkynyl, or R1 represents H, and R2 represents fluorine, bromine, iodine, ethyl, C5-7 alkyl, C2-7 alkenyl, or lower alkynyl; N-oxides and tautomers thereof, and salts of these amides of anthranilic acid, their N-oxides and tautomers; processes for its preparation; pharmaceutical compositions and the use of this compound, alone or in combination with one or more different pharmaceutically active compounds, for the preparation of a pharmaceutical composition for the treatment of a neoplastic disease, retinopathy or age-related macular degeneration. |