http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-037135-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 |
| filingDate | 2002-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-037135-A1 |
| titleOfInvention | ADENOSINE DERIVATIVES WITH AN ACETYLENE GROUP IN 4 'POSITION, WITH AGENIST ACTIVITY OF ADENOSINE A1 RECEIVER |
| abstract | Compounds of 6 substituted amino purines of formula (1), where: X represents O or CH2; R1 represents: (i) cycloalkyl (C3-9) - (alq) n- or cycloalkenyl (C3-9) - (alq) n-, the cycloalkyl or cycloalkenyl group being optionally substituted by one or more substituents selected from OH, halogen , C1-6 alkyl, -C 1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy and phenyl, wherein (alq) represents C1-3 alkyl and n represents 0 or 1, and the group (alq) may optionally be substituted by the C3-6 cycloalkyl group; (ii) a phenyl group optionally substituted by one or more substituents selected from: halogen, CF3, cyano, -C1-6alkyl, -C2-6alkyl, -C2-6alkyl-, C1-6alkoxy-, -alkyl OH C1-6, -CO2H and -CO2 C1-6 alkyl; iii) a C4-7 heterocyclic group containing at least one heteroatom selected from O, N or S, and optionally substituted by one or more substituents selected from OH, -C1-6 alkyl-, -C 1-6 alkoxy, -CO2C1 alkyl -4, -C 1-4 alkyl, -CO 2 -aryl or (C 3-6) cycloalkyl-CO 2 (alk) n, where (alk) represents C 1-3 alkyl and n represents 0 or 1; (iv) a straight or branched C1-12 alkyl group optionally substituted by one or more groups selected from phenyl, halogen, hydroxy, and C3-7 cycloalkyl, where one or more carbon atoms of the C1-12 alkyl group can be replaced optionally by a group independently selected from S (= O) n (where n is 0, 1 or 2) and N; (v) a molten bicyclic ring of formula (2) wherein A represents C4-6 cycloalkyl or phenyl and B represents phenyl optionally substituted by C1-3alkyl and the bicyclic ring is linked to the purine-6-amino portion by a ring atom of ring A; R2 represents a C1-3 alkyl, halogen, hydrogen or C1-3 alkoxy group; R3 and R4 independently represent H or a C1-6 alkyl group; or a pharmaceutically acceptable salt and / or solvate thereof. Also disclosed are: pharmaceutical compositions containing them, their use in the manufacture of a medicament for the treatment of a patient suffering from a condition where it is advantageous to reduce the concentration of free fatty acids in plasma or reduce the heart rate and method for treatment in a patient with said condition. |
| priorityDate | 2001-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.