| abstract |
Anti-herpes virus compounds that are not nucleosides of the formula (1) in which: R is selected from the group consisting of hydrogen, lower alkyl, amino, lower alkyl-amino, di (lower alkyl) -amino, lower alkanoyl -amino, (lower alkoxy-carbonyl) -amino, di (lower alkoxy-carbonyl) -amino, {(lower alkyl-amino) carbonyl} -amino and pyridinylamino; and Z is selected from the group consisting of amino-substituted reverse amides, substituted amides, amino-substituted alkoxy and (aminocarbonyl) -alkyl. The compounds inhibit herpes helicase-primase. Procedure to prepare them, pharmaceutical composition that contains them, method to inhibit the replication of a herpes virus, method to treat a herpes infection in a mammal, helicase-primase inhibitor of herpes, method to identify it and pharmaceutical composition that contains it. |